Dağoğlu, GürdalÖzbek, HanefiKatı, İsmailTekin, Murat2019-07-162019-07-1620041017-8422https://trdizin.gov.tr/publication/paper/detail/TnpJeU5EVTE=https://hdl.handle.net/20.500.12483/821Rezene bitkisi eterik yag ekstresinin analjezik etkisinin arastırıldıgı bu çalısmada 50 adet fare kullanıldı. Fareler bes gruba ayrıldı: I. gruba (kontrol) periton içi yolla (i.p.) 0.2 ml serum fizyolojik (SF), II. gruba (referans) oral yolla (p.o.) 100 mg/kg aspirin, III. gruba (referans) derialtı yolla (s.c.) 10 mg/kg morfin HCl, IV. gruba i.p. yolla 0.25 ml/kg rezene eterik yagı (REY) ve V. gruba i.p. 0.50 ml/kg REY uygulandı. Uygulama öncesinde ve uygulamadan sonraki 30., 90. ve 150. dakikalarda çalısma grupları tail-flick cihazı ile test edildi. Veriler varyans analiziyle degerlendirildi. Aspirin grubunun çalısmanın 150. dakikasında SF grubuna göre anlamlı seviyede analjezik etki gösterdigi, morfin HCl grubunun ise çalısmanın 30. ve 90. dakikalarında diger tüm çalısma gruplarına göre anlamlı derecede analjezik etki gösterdigi, fakat çalısmanın tüm evrelerinde REY’nın her iki dozunun da analjezik etkisinin bulunmadıgı saptanmıstır.In this study, 50 mice were used to investigate the analgesic effect of Foeniculum vulgare Miller (Fennel) etheric oil extracts. The experimental protocol were approved by the Animal Research Committee of University of Yuzuncu Yil. The animals divided into five groups: The animals in Group I (Control group) were given 0.2 ml of 0.9 % NaCl solution i.p. , Group II (referance) were dosed with 100 mg/kg aspirin p.o. , Group III (referance) were treated with 10 mg/kg morphine HCl s.c., the mice in Group IV and Group V were administered etheric oil extract of Foeniculum vulgare at doses of 0.25 ml/kg and 0.50 ml/kg i.p. respectively. Animals were tested using tail-flick instrument before treatments and at 30th, 90th and 150th minutes after treatments. Obtained all data were analyzed with One-way analysis of variance (ANOVA). At 150th minute, it was found that aspirin has analgesic effect significantly compared with control group. morphine HCl showed higher analgesic effect at 30th and 90th minutes than other groups. Foeniculum vulgare etheric oil extract at both of doses did not showed analgesic effect significantly.trinfo:eu-repo/semantics/openAccessVeterinerlikArticle151-22326