Uysal, AlperGuntel, MuratDemetgül, ÖzcanÇiçek, Ulaş2024-09-192024-09-1920231108-7161https://hdl.handle.net/20.500.12483/14944Objectives: Both Parkinson’s disease (PD) and osteoarthritis (OA) are characterized by chronic inflammation and tissue degeneration. The aim of this study is to investigate the relationship between PD and distal femoral cartilage thickness (DFCT). Our study is the first in the literature to measure DFCT in PD. Methods: 68 patients with PD and 30 healthy individuals participated. The patient group was divided into three subgroups, according to the Hoehn Yahr stages (HYS): mild, moderate and severe. Patient subgroups and the control group were compared with each other in terms of neutrophil-lymphocyte ratio (NLR), C-reactive protein (CRP), and DFCT. Results: The NLR and CRP levels of the PD patients were higher than the values of the healthy people. The DFCT values of the mild PD subgroup were significantly higher than those of the control group, except for one value. The DFCT values of the moderate PD subgroup and the healthy group were similar. The DFCT values of the severe PD subgroup were lower than the values of the healthy group. Conclusions: Our study showed the presence of ultrasonographic evidence consistent with early signs of cartilage destruction in early-stage PD disease. As the PD stage progressed, the cartilage thickness decreased accordingly. © 2023, International Society of Musculoskeletal and Neuronal Interactions. All rights reserved.eninfo:eu-repo/semantics/closedAccessDistal Femoral Cartilage ThicknessInflammationOsteoarthritisParkinson’s DiseaseUltrasoundArticle233328337376542182-s2.0-85170295251Q2