Aydin, A. E.2024-09-182024-09-1820201070-42801608-3393https://doi.org/10.1134/S1070428020050255https://hdl.handle.net/20.500.12483/9770Chiral norephedrine-derived beta-amino alcohols with a thiophene moiety were synthesized from thiophene carbaldehydes (methyl- or ethyl-substituted) and chiral amino alcohols, such as both enantiomers of norephedrine and 2-aminopropanol. The synthesized ligands were applied to the catalytic asymmetric addition of diethylzinc to aldehydes to obtain optically active alcohols with a high conversion (92%) and excellent enantioselectivities (eeup to 99%). The highest enantioselectivity (ee99%) was obtained withp-trifluorobenzaldehyde as the substrate containing the strongly electron-acceptor CF(3)group.eninfo:eu-repo/semantics/closedAccessenantioselective synthesischiral amino alcoholsthiolated amino-alcohols12-additionArticle56590190910.1134/S10704280200502552-s2.0-85086862955Q4WOS:000543420200025Q4