Ozcan, M.Teughels, W.Alkaya, B.Turer, O.U.Selimli, F.Kayhan, H.G.Yıldız, H.S.2024-09-192024-09-1920241876-2883https://doi.org/10.1163/18762891-BJA00030https://hdl.handle.net/20.500.12483/15195The aim of this animal study was to compare the primary/secondary stability and micro-CT bone and tissue volumes of implants that were immersed in Limosilactobacillus reuteri, cholecalciferol-D3 (vitamin D) and injectable platelet-rich fibrin (i-PRF) suspensions/solutions before placement in bone. 40 implants (10 in each group) were placed in the iliac crest of 5 sheep. The implants were immersed in L. reuteri, vitamin D or i-PRF solutions for five minutes before placement or left unsoaked as controls. Implant stability was determined by ISQ values and bone volume around implants was histomorphometrically analysed by micro-CT evaluation. At 4 weeks, implants in the L. reuteri group showed the highest secondary stability and 2- and 3D BV/TV values. Both L. reuteri and vitamin D immersed implants had higher osseointegration values compared to the implants in the i-PRF group and controls. There were no statistical differences between L. reuteri and vitamin D immersed implants. Within the limits of the study, the results suggest that immersing implants in L. reuteri or vitamin D suspensions/solutions before implant placement in bone may have beneficial effects on osseointegration. © M. OZCAN et al., 2024.eninfo:eu-repo/semantics/closedAccessi-PRFosseointegrationprobioticsurface biomodificationvitamin DArticle15552753610.1163/18762891-BJA00030391473742-s2.0-85201716094Q1