Meydan, S.Altas, M.Nacar, A.Ozturk, O. H.Tas, U.Zararsiz, I.Sarsilmaz, M.2024-09-182024-09-1820120960-32711477-0903https://doi.org/10.1177/0960327112457187https://hdl.handle.net/20.500.12483/11470Objective: Toluene is used as an organic solvent, and it has neurotoxic effects. Omega-3 is an essential fatty acid required for brain development. The aim of this study was to investigate the protective effects of omega-3 fatty acid against toluene-induced neurotoxicity in prefrontal cortex of rats. Materials and methods: A total of 21 male Wistar rats were divided into three groups with seven rats in each group. Rats in group I were the controls. Toluene was intraperitoneally injected into the rats of group II with a dose of 0.5 ml/kg. Rats in group III received omega-3 fatty acid with a dose of 0.4 g/kg/day while exposed to toluene. After 14 days, all the rats were killed by decapitation. Enzymatic activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and the level of malondialdehyde (MDA) were spectrophotometrically studied in the prefrontal cortex of rats. Results: Enzymatic activities of SOD and GSH-Px were decreased, and MDA levels were significantly increased in rats treated with toluene compared with the controls. However, the increased SOD and decreased GSH-Px enzymatic activities and MDA levels were detected in the rats administered with omega-3 fatty acid while exposed to toluene. Conclusion: The results of this experimental study indicate that omega-3 fatty acid treatment can prevent toluene-induced neuronal damage in the prefrontal cortex of rats.eninfo:eu-repo/semantics/openAccessOmega-3 fatty acidtolueneprefrontal cortexratArticle31111179118510.1177/0960327112457187230796682-s2.0-84869057309Q2WOS:000310884800010Q4