Duzguner, VesileKucukgul, AltugErdogan, SuatColik, SefaSahin, Kazim2024-09-182024-09-1820080971-21190974-1844https://doi.org/10.1080/09712119.2008.9706888https://hdl.handle.net/20.500.12483/9484To evaluate the role of lycopene, a carotenoid antioxidant, on streptozotocin (STZ)-induced diabetic rats, 12 female rats received a single intraperitonial injection of STZ at a dose of 45 mg/kg body weight of which 6 were given 10 mg/kg lycopene orally (test group) once daily for 21 days. The administration of STZ caused a significant increase in plasma glucose and decrease in body weight. The supplementation of lycopene significantly reduced diabetic plasma glucose level by 25% and prevented body weight loss starting from 14(th) day of lycopene administration. Although tissue lipid peroxidation and nitric oxide (NO) levels were unchanged, lycopene administration significantly reduced diabetes-elevated lipid peroxidation and NO in plasma. It was concluded that lycopene supplementation may be valuable for correcting hyperglycemia and preventing diabetic complications caused by lipid peroxidation and free radicals.eninfo:eu-repo/semantics/closedAccessdiabeteslipid peroxidationlycopeneSTZratArticle331172010.1080/09712119.2008.97068882-s2.0-48249149180Q2WOS:000255109100004Q4