Akçora, BülentAltu?, Muhammed EnesÖztürk, AtakanÖzer, Cahit2024-09-192024-09-1920091300-2996https://hdl.handle.net/20.500.12483/14230The purpose of this study is to evaluate whether administration of tranexamic acid (TNA), an anti-fibrinolytic drug, would decrease amount of bleeding on splenic laceration model in rats. Fourteen Sprague-Dawley male rats were randomly divided into two groups each contain 7 rats. Group 1 was splenic laceration + %0.9 NaCl infusion; group 2 was splenic laceration + %0.9 NaCl infusion + TNA treatment. All rats were sacrificed at the end of 60 minutes. The groups were evaluated in terms of hematocrite changes and the amount of intra-abdominal blood accumulations. There were significant difference between preoperative and post-operative hematocrite (Hct-1 and Hct-2, respectively) levels of the two groups (p<0.05). Hct-2 level of group 2 was higher than that of group 1, but it was not significantly important (P=0.097). Blood loss of rats in group 2 was less than in group 1, but it was not significantly important (P=0.073), as well. We can say that using TNA has a tendency, although not statistically significant, to decrease of intraperitoneal hemorrhage from a lacerated spleen in rats. This treatment method may yield better results when used in other animal species which have similar coagulation properties with human. © 2009 OMÜ Tüm Haklari Saklidir.trinfo:eu-repo/semantics/closedAccessAcideAntifibrinolyticHemorrhageHemostasisSpleenTranexamicTraumaArticle2641691722-s2.0-80053645917#BAŞV!