Gokcek, Ishak2024-09-182024-09-1820240028-12981432-1912https://doi.org/10.1007/s00210-023-02828-4https://hdl.handle.net/20.500.12483/8866This study investigated the cardioprotective effect of oleuropein against cisplatin-induced cardiac damage in terms of inflammatory, oxidative stress and cardiac parameters. In this study, 40 female Wistar albino rats were divided into four groups: control, cisplatin, oleuropein and cisplatin+oleuropein. To establish the experimental model, oleuropein (200 mg/kg) was administered for 14 days and cisplatin (7 mg/kg) was administered as a single dose on the seventh day. Cisplatin increased MDA cardiac parameters (CK, CK-MB and cTnI) and inflammatory cytokines (TNF-alpha, IL-1 beta and IL-6) in cardiac tissue and decreased GSH, GSH-Px and catalase levels. On the other hand, oleuropein improved cardiac parameters and decreased inflammatory cytokine and oxidative stress levels in cardiac tissue.eninfo:eu-repo/semantics/closedAccessCisplatinOleuropeinCardioprotective effectRatArticle39753403341010.1007/s00210-023-02828-4379556922-s2.0-85176361637Q2WOS:001104640000001Q2