Fentoğlu, ÖzlemTülüceoğlu, Eda EvgenDoğan, Esra Sinem KemerDoğan, Burak2024-09-192024-09-1920222822-2555https://doi.org/10.54614/CRDS.2022.6203https://search.trdizin.gov.tr/tr/yayin/detay/1119927https://hdl.handle.net/20.500.12483/15116Objective: Periodontal diseases are chronic inflammatory pathologies including in pro-inflammatory cyto-kine-mediated pathogenesis and epigenetic characteristics. We aimed to evaluate pro-inflammatory cytokine [interleukin (IL)-1?, tumour necrosis factor-alpha (TNF-?), and IL-6] gene polymorphisms in patients with periodontal disease. Methods: Patients with periodontitis (n = 25), gingivitis (n = 22), and periodontally healthy controls (n = 18) were enrolled in this study. The periodontal parameters (plaque index, gingival index, probing pocket depth, percent-age of bleding on probing, and clinical attachment level) were recorded, and fasting venous blood samples were obtained. The genotypes and allele frequencies of TNF?-308,-238, IL-1?-511, +3953, IL-6-174,-572 polymor-phisms were performed using polymerase chain reaction–restriction fragment length polymorphism technique. Results: Patients with periodontitis had the highest IL-1? +3953, IL-6-174 ve TNF-?-238 heterozygot geno-types, clinical periodontal parameters and demographic characteristics. IL-1? +3953 [the risk allele 2 (A allele) (GA genotype)] led to an increased risk of periodontitis, IL-6-174 [the risk allele 2 (G/T allele) (CG/CT genotypes)] was associated with gingivitis. Conclusion: Our findings provide important evidence that pro-inflammatory cytokine gene polymorphisms may be involved in the pathogenesis of gingivitis and periodontitis. Control of the cytokine response associated with periodontal diseases may constitute a step towards improving public health by reducing mortality and morbidity rates associated with many infectious-inflammatory diseases. © 2022, AVES. All rights reserved.trinfo:eu-repo/semantics/openAccessgingivitisinterleukin-1 betaInterleukine-6periodontitispolymorphismtumor necrosis factor alphaArticle32319620010.54614/CRDS.2022.62032-s2.0-85169463143Q41119927