Aydogan, AkinAkkucuk, SeckinOzkan, Orhan VeliAydin, MehmetMotor, SedatUgur, MustafaOruc, Cem2024-09-192024-09-1920140393-6384https://hdl.handle.net/20.500.12483/14239Aim: Ghrelin and peptide YY are gut hormones that have an anti-inflammatory effect by inhibiting proinflammatory cytokines. We aimed to determine the anti-inflammatory and protective effects of ghrelin and Peptide YY. Methods: The study group included 28 patients with acute biliary pancreatitis and 38 controls. Ghrelin, peptide YY, IL-6, TNF-?, amylase, lipase, glucose, alanine aminotransferase, aspartate aminotransferase, leucocyte count, and hematocrit were measured three times in each patient and once in the control group. Results: Ghrelin levels tended to increase as treatment continued, but still were below the levels in the control group. On the other hand, peptide YY levels in all of the patient samples were higher than in the control group (p>0.001). Conclusion: Ghrelin is proposed as a protective hormone for acute pancreatitis. Exogenous ghrelin exhibits protective activity in caerulein-induced pancreatitis. All previous in vivo and in vitro studies have reported that exogenous PYY administration inhibited inflammation and had protective effects. This study indicates for the first time that endogenous PYY has protective effects on pancreatitis via the inhibition of inflammation, and that these effects are stronger than the effects of ghrelin.eninfo:eu-repo/semantics/closedAccessAcute biliary pancreatitisGhrelinGut hormonePeptide YYArticle3023233272-s2.0-84898435914N/A