Özbakiş Akkurt, B. Ça?laInano?lu, KeremTurhano?lu, SelimAsfuro?lu, Zeynel2024-09-192024-09-1920081300-0578https://hdl.handle.net/20.500.12483/14346Objective: Dexmedetomidine is a selective ?2-adrenergic receptor blocker with sedative and analgesic effects. It has been shown to reduce postoperative pain and morphine consumption but its clinical use is limited because of its potential cardiovascular side effects. Tramadol is an opioid analgesic with a similar potency to meperidine. Although it is not as potent as morphine, it is preferred in clinical practice because of its relatively low potential side effects. We aimed to compare the effect and side effects of preoperative dexmedetomidine or tramadol administration on postoperative pain and analgesic consumption. Method: Sixty patients were randomly assigned into three groups to receive lmg kg-1 iv tramadol, or l ?g kg-1 iv dexmedetomidine, or the same volume of saline before induction of anaesthesia. At the time of skin closure, patients were given a standardized bolus dose of morphine and then were allowed to use a patient controlled analgesia (PCA) device. Blood pressures and heart rate were recorded before and after the infusion of the drugs and induction and 1 minute after intubation. Sedation, pain score, cumulative morphine consumption and side effects were recorded 15 minutes, and 2, 6, 12, and 24 hours after initiation of PCA. Results: There were decrease in the blood pressures and heart rates of the patients in the dexmedetomidine group (p<0.05). Postoperative pain and morphine consumption were significantly reduced in the dexmedetomidine group (Group T: 29.87 mg, Group D: 20.95 mg, p<0.05). VAS was lower in the dexmedetomidine group and postoperative sedation scores were higher in the dexmedetomidine group in the first 6 hours. Conclusion: Preoperative dexmetedomidine reduced postoperative morphine consumption more effectively than tramadol without an important adverse effect on hemodynamic parameteres.trinfo:eu-repo/semantics/closedAccessAnalgesiaDexmedetomidinePostoperative painTramadolArticle1641831872-s2.0-60149107808Q4