Çek, ŞehribanGökçe, M. Ali2024-09-192024-09-1920061812-5735https://doi.org/10.3923/pjbs.2006.1486.1491https://hdl.handle.net/20.500.12483/15210The present study examined changes in the concentrations of plasma testosterone (T), progesterone (P4) and estradiol-17? (E2) to determine changes in serum hormone profiles during the functional female phases in Sparus aurata. The fish were treated with [D-Ala6 Pro9 NEt]- luteinizing hormone releasing hormone analogue (LHRHa) alone, LHRHa plus pimozide (PIM) and Physiological Saline (PS) alone to stimulate gonadal development and sexual maturation. All fish were sampled and plasma levels of oestradiol (E2) Testosterone (T) and progesterone (P4) were measured by radioimmuno assay. LHRHa treatment alone, or in combination with PIM, elevated serum E2 and T concentrations (p<0.05) at 6, 24, 48 h after treatments while plasma P4 concentrations were unaffected by the treatments (p>0.05). Vitellogenesis was also stimulated by a combined LHRHa and PIM treatment. Responses to treatment with LHRHa plus PIM were comparable to those treated with LHRHa alone (p>0.05), suggesting that dopamine receptor antagonist, pimozide may not inhibit dopamine secretion in S. aurata. © 2006 Asian Network for Scientific Information.eninfo:eu-repo/semantics/closedAccessLHRHaPimozideSex steridsSparus aurataArticle981486149110.3923/pjbs.2006.1486.14912-s2.0-33749664279Q3