Balta, IlknurEkiz, OzlemOzuguz, PinarUstun, IhsanKaraca, SemsettinKacar, Seval DogrukEksioglu, Meral2024-09-182024-09-1820150011-90591365-4632https://doi.org/10.1111/ijd.12426https://hdl.handle.net/20.500.12483/13468BackgroundPost-adolescent acne has been defined as acne in a patient aged >25years. Acne vulgaris first develops at the onset of puberty as a result of hormonal changes. During puberty, there is a transient decline in insulin sensitivity. We hypothesized that insulin resistance might persist after puberty in patients with post-adolescent acne. ObjectivesThis study was conducted in order to investigate the relationship between post-adolescent acne and insulin resistance. MethodsThe study population comprised 35 patients with post-adolescent acne and 35 healthy control subjects. The parameters measured were fasting blood glucose, insulin, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), total cholesterol (TC), triglycerides, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). The homeostasis model assessment of insulin resistance (HOMA-IR) index was calculated for each individual. ResultsNo significant differences were observed between patients with post-adolescent acne and control subjects in fasting blood glucose, fasting insulin, AST, ALT, triglyceride and HDL-C levels, and HOMA-IR index. There were also no correlations between these parameters and the severity of acne. ConclusionsThis study suggests that insulin resistance may not play a major role in the pathogenesis of post-adolescent acne. Hormonal changes, genetic susceptibility, stress, the use of cosmetics, drugs, and environmental factors should be considered in the development of post-adolescent acne.eninfo:eu-repo/semantics/closedAccessHomeostasis Model AssessmentGlycemic IndexClinical-FeaturesVulgarisPrevalenceGlucoseAdultsArticle54666266610.1111/ijd.12426249619252-s2.0-84929606811Q1WOS:000355135300027Q3