Arslan, HakanDuran, NizamiBorekci, GulayOzer, Cemal KorayAkbay, Cevdet2024-09-182024-09-1820091420-3049https://doi.org/10.3390/molecules14010519https://hdl.handle.net/20.500.12483/12554Five thiourea derivative ligands and their Ni2+ and Cu2+ complexes have been synthesized. The compounds were screened for their in vitro anti-bacterial activity using Gram-positive bacteria (two different standard strains of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Streptococcus pyogenes, Bacillus cereus) and Gram-negative bacteria (Esherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Proteus vulgaris, Enterobacter aerogenes) and in vitro anti-yeast activity (Candida albicans, Candida krusei, Candida glabrata, Candida tropicalis, Candida parapsilosis). The minimum inhibitory concentration was determined for all ligands and their complexes. In vitro anti-yeast activity of both ligands and their metal complexes is greater than their in vitro anti-bacterial activity. The effect of the structure of the investigated compounds on the antimicrobial activity is discussed.eninfo:eu-repo/semantics/openAccessThiourea derivativesComplexesAntibacterial activityAntifungal activityIn vitro studiesLipophilicityArticle14151952710.3390/molecules14010519191691992-s2.0-59349086386Q1WOS:000262791200041Q3