Sartelli, MassimoAbu-Zidan, Fikri M.Catena, FaustoGriffiths, Ewen A.Di Saverio, SalomoneCoimbra, RaulOrdonez, Carlos A.2024-09-182024-09-1820151749-7922https://doi.org/10.1186/s13017-015-0055-0https://hdl.handle.net/20.500.12483/10690Background: To validate a new practical Sepsis Severity Score for patients with complicated intra-abdominal infections (cIAIs) including the clinical conditions at the admission (severe sepsis/septic shock), the origin of the cIAIs, the delay in source control, the setting of acquisition and any risk factors such as age and immunosuppression. Methods: The WISS study (WSES cIAIs Score Study) is a multicenter observational study underwent in 132 medical institutions worldwide during a four-month study period (October 2014-February 2015). Four thousand five hundred thirty-three patients with a mean age of 51.2 years (range 18-99) were enrolled in the WISS study. Results: Univariate analysis has shown that all factors that were previously included in the WSES Sepsis Severity Score were highly statistically significant between those who died and those who survived (p < 0.0001). The multivariate logistic regression model was highly significant (p < 0.0001, R-2 = 0.54) and showed that all these factors were independent in predicting mortality of sepsis. Receiver Operator Curve has shown that the WSES Severity Sepsis Score had an excellent prediction for mortality. A score above 5.5 was the best predictor of mortality having a sensitivity of 89.2 %, a specificity of 83.5 % and a positive likelihood ratio of 5.4. Conclusions: WSES Sepsis Severity Score for patients with complicated Intra-abdominal infections can be used on global level. It has shown high sensitivity, specificity, and likelihood ratio that may help us in making clinical decisions.eninfo:eu-repo/semantics/openAccessIntra-abdominalInfectionsSepsisSeptic shockArticle1010.1186/s13017-015-0055-0266773962-s2.0-84949808332Q1WOS:000366547000001Q2