Demirtaş, Abdullah OrhanUrgun, Örsan DenizKoca, HasanKaypaklı, Onurİçen, Yahya KemalKoç, Mevlüt2020-09-032020-09-032019Demirtaş, A. O. (2019). Tp-e interval and Tp-e/QTc ratio are significantly increased in patients with brain death. Acta Medica, 50(3), 25-31.2147-9488https://dx.doi.org/10.32552/2019.ActaMedica.363https://hdl.handle.net/20.500.12483/3018Objective: We aimed to investigate whether there is a change in Tp-e interval, Tp-e/ QT and Tp-e/QTc ratios in patients with brain death. Materials and Methods: Fifty brain death patients and 50 age and sex matched healthy controls were included in the study. In addition to routine evaluation, Tp-e interval, Tp-e / QT and Tp-e / QTc ratios were measured in 12-lead electrocardiography. Tp-e was measured in the precordial leads using the Tail method; the time from the peak of the T wave to the point where the wave reached the isoelectric line. Results: White blood cell, aspartate aminotransferase, alanine aminotransferase and high sensitive c reactive protein levels were significantly higher in patients with brain death. The frequency of patients with QTc prolongation, Tp-e interval, Tp-e/QT and Tp-e/QTc values were significantly higher in patients with brain death (p <0.05). Tp-e interval, Tp-e/QT and Tp-e/QTc values were found to be positively correlated with HsCRP (p<0.001 for all). Conclusion: Tp-e interval, Tp-e / QT and Tp-e / QTc ratios are increased in patients with brain death compared to healthy controls. The mechanisms of this association and possible relationship with neuroendocrine changes should be investigated in future studies.eninfo:eu-repo/semantics/openAccessAttribution-ShareAlike 3.0 United StatesTp-e intervalTp-e/QTc ratioBrain deathQT intervalArticle503253110.32552/2019.ActaMedica.363