Demir, EmelDuzguner, VesileAtici, AhmetYengil, Erhan2024-09-182024-09-1820240882-5963https://doi.org/10.1016/j.pedn.2023.11.004https://hdl.handle.net/20.500.12483/12770Background: With the Virtual Reality (VR) technique, 3D movies can be made for refugee children for pre-operative stress. The study aims to reveal the oxidative responses of the VR technique in pre-operative anxiety in elective surgery in children aged 5-12 years. Methods: The Study was designed according to the CONSORT checklist with a randomized controlled parallel de-sign. The whole sample (n = 23), VR experimental group (n = 12), and control group (n = 11) were determined according to the total count method prospectively in 6 months. Oxidative stress parameters (Cortisol, Malondialdehyde, Nitric oxide, Glutathione) were measured in blood samples from the first hospitalization (beginning) and before the intervention (pre-operative) in the experimental and control groups. Findings: MDA, NO, and cortisol levels (p < 0.05), which indicate the stress level, are high in all groups. In pre-operative measurements, oxidative parameters were lower in the VR experimental group than in the control group. At the same time, the anti-stress antioxidant factor Glutathione was higher in the VR experimental group in pre-operative measurements.Discussion: The application of 3D film as a VR technique reduces stress parameters in pre-operative stress, and its antioxidant system activating effect has been determined.Application to practice: It can be applied to refugee child groups for pre-operative stress by shooting 3D movies in different languages.(c) 2023 Published by Elsevier Inc.eninfo:eu-repo/semantics/closedAccessVirtual realityOxidative stressRefugee childrenPre-operative periodArticle75808810.1016/j.pedn.2023.11.004381183012-s2.0-85180290940Q1WOS:001143770000001Q2