Özcan, OğuzhanDoğan, SerdarÇiçek, GünerKaçmaz, FilizOğuzman, HamdiArpacı, Abdullah2024-09-192024-09-1920240250-4685https://doi.org/10.1515/tjb-2023-48s105https://hdl.handle.net/20.500.12483/14268Objectives: This study investigated the effect of aerobic exercise on serum irisin, preptin levels in overweight women and their relationship with routine biochemical tests. Methods: The study included 25 healthy controls and 25 overweight sedentary women (BMI>25). The exercise training was performed 3 days a week for 12 weeks. Anthropometric measurements were performed and fasting blood samples were collected before and after exercise period. All samples were centrifuged at 1500xg for 10 minutes and the serum was separated. Serum irisine and preptin levels were analyzed by ELISA method. Routine biochemical parameters were assayed by spectrophotometric, hsCRP levels by nephelometric and insulin levels by immunoassay method using auto analyzers. Results: There was a significant decrease in BMI and fat mass in the post-exercise group compared with pre-exercise (p<0.001). Serum irisin levels were significantly lower in pre- and post-exercise group compared to controls (p<0.001), but no significant change was observed after exercise period. Preptin levels were significantly higher in the pre-exercise group (median/IQR, 558.2 /351,2-756,8 pg/ml) compared to the controls (median / IQR, 137.1/85.2-427.9 pg/ ml), and significantly reduced in post-exercise group (medium/IQR, 243.1/179.2-330 pg/ml) compared to pre-exercise group. In the pre-exercise group, a significant negative correlation was observed between irisin and body mass index (r=-0.443, p=0,027), while a positive correlation was found between preptin and body weight (r=0.438, p=0.029). Conclusions: Twelve weeks of aerobic exercise in overweight sedentary women has lowering effect on serum preptin levels but no effect on serum irisin levels. © 2024 De Gruyter Open Ltd. All rights reserved.eninfo:eu-repo/semantics/openAccessaerobic exerciseirisinoverweightpreptinArticle48s16113610.1515/tjb-2023-48s1052-s2.0-85187149220Q3