Carsanba, ErdemPapanikolaou, SeraphimFickers, PatrickErten, Huseyin2024-09-182024-09-1820190749-503X1097-0061https://doi.org/10.1002/yea.3389https://hdl.handle.net/20.500.12483/8089Citric acid (CA) productivity by Yarrowia lipolytica dependents on strain type, carbon source, carbon to nitrogen (C/N) molar ratio as well as physicochemical conditions (pH, temperature, oxygen transfer rate, etc.). In the current study, 10 different Y. lipolytica strains were first challenged in shake-flask culture for CA production in a glucose-based media under nitrogen-limited conditions. For the most promising one, strain K57, CA productivity was monitored during culture in batch bioreactor for three initial C/N molar ratio (167, 367, and 567 Cmol/Nmol). The highest CA yield (0.77 g/g glucose), titre (72.3 g/L CA), and productivity (0.04 g/g.h) were found for C/N ratio of 367. However, the highest growth rate was obtained for an initial C/N ratio of 167. From these results, Y. lipolytica strain K57 could be considered to produce CA at higher titre on glucose-based medium in batch bioreactor than others Y. lipolytica strain reported in the literature.eninfo:eu-repo/semantics/closedAccessbatch bioreactor cultureCN molar ratiocitric acidYarrowia lipolyticaArticle36531932710.1002/yea.3389309457722-s2.0-85067236275Q2WOS:000471600700008Q2