Akkus, GamzeSokmen, YelizYilmaz, MehmetBekler, OzkanAkkus, Oguz2024-09-182024-09-1820211871-53032212-3873https://doi.org/10.2174/1871530320666200729145100https://hdl.handle.net/20.500.12483/12580Background: We aimed prospectively to investigate the laboratory and electrocardiographic parameters (heart rate, QRS, QT, QTc, Tpe, Tpe/QTc, and arrhythmia prevalence) in patients with Graves' disease before and after antithyroid therapy. Methods: Seventy-one patients (48 female, and 23 male), of age between 18-50 years (mean +/- SD: 36.48 +/- 12.20) with GD were included in the study. Patients were treated with antithyroid therapy (thioamides and/or surgical therapy) to maintain euthyroid status. Patients were examined in terms of electrocardiographic parameters before and after the treatment. Results: Mean TSH, free thyroxin (fT(4)), and tri-iodothyrionine (fT(3)) levels of all patients were 0.005 +/- 0.21, 3.27 +/- 1.81, 11.42 +/- 7.44, respectively. While 9 patients (group 2) underwent surgical therapy, had suspicious malignant nodule or large goiter, and unresponsiveness to medical treatment; the other patients (n=62, group 1) were treated with medical therapy. Patients with surgical therapy had more increased serum fT4 (p=0.045), anti-thyroglobulin value (p=0.018) and more severe graves orbitopathy (n=0.051) before treatment when compared to a medical therapy group. Baseline Tpe duration and baseline Tpe/QTc ratio and frequency of supraventricular ectopic beats were found to be significantly higher in group 2 when compared to group 1 (p=0.00, p=0.005). Otherwise, the baseline mean heart rate, QRS duration, QTc values of both groups were similar. Although the patients came at their euthyroid status, group 2 patients still suffered from more sustained supraventricular ectopics beats than group 1. Conclusion: Distinct from the medical treatment group, surgical treatment group with euthyroidism for at least 3 months still suffered from an arrhythmia (Tpe, Tpe/QTc, supraventricular and ventricular ectopic beats).eninfo:eu-repo/semantics/closedAccessThyrotoxicosisarrhythmiaanti-thyroid therapyGraves' DiseasehyperthyroidismelectrocardiogramArticle21118319110.2174/1871530320666200729145100327273362-s2.0-85101076855Q2WOS:000613440100019Q4