Cakirca, GokhanCelik, Muhammet Murat2024-09-182024-09-1820180250-46851303-829Xhttps://doi.org/10.1515/tjb-2017-0227https://hdl.handle.net/20.500.12483/10005Objectives: We aimed to assess the growth arrest specific protein 6 (Gas6) and soluble Axl (sAxl) levels in the familial Mediterranean fever (FMF) patients, and to investigate the correlation between the levels of these with the inflammatory markers including C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and fibrinogen. Materials and methods: Seventy nine FMF patients (35 in attack period and 44 in attack-free period) and 40 healthy controls were involved in the study. The levels of serum Gas6 and sAxl were measured by enzyme-linked immuno-sorbent assay (ELISA) method. Results: Gas6 levels of the FMF patients with attack were significantly lower than both the attack-free patients and the healthy controls (p = 0.007 and p = 0.003, respectively). However, no significant difference was detected between the Gas6 levels of the attack-free patients and the healthy controls (p > 0.05). sAxl levels of the FMF patients with attack were significantly lower than the healthy control (p = 0.007). A positive correlation was found between the Gas6 and CRP levels of the FMF patients with attack (r = 0.379, p = 0.025). Conclusions: This study indicates that decreased serum Gas6 and sAxl levels may be associated with FMF attack period. Further studies on the role of the Gas6/Axl system in FMF are needed.eninfo:eu-repo/semantics/openAccessFamilial Mediterranean feverGrowth arrest specific 6Tyrosine kinase receptorInflammationApoptosisArticle43547548010.1515/tjb-2017-02272-s2.0-85041198763Q3WOS:000449635800001Q4