Tambag, Ali KazimKazak, FilizAkalin, Pinar PekerKutlu, Tuncer2024-09-182024-09-1820212667-4440https://doi.org/10.5152/turkjnephrol.2021.4731https://search.trdizin.gov.tr/tr/yayin/detay/455444https://hdl.handle.net/20.500.12483/11150Objective: This study was purposed to investigate the possible protective effects of rutin on kidney tissue in a methotrexate-induced nephrotoxicity rat model. Methods: Rats were randomly divided into 4 groups: control group, methotrexate (MTX, 20 mg/kg) group, rutin (RUT, 50 mg/kg/day) group, and methotrexate + rutin (MTX+RUT, 20 mg/kg + 50 mg/kg/day, respectively) group. Biochemical and histopathological analyzes were performed on kidney tissues of rats at the end of the study. Results: It was determined that kidney tissue damage determined in the MTX group was decreased in the MTX + RUT group; there were no degenerative changes in the tubular epithelium of the MTX + RUT group, and only mild degenerative changes were observed rather than hydropic degeneration seen in MTX group. Conclusion: This study suggests that rutin can be effective in preventing the toxic effects of methotrexate on the kidney.eninfo:eu-repo/semantics/openAccessMethotrexatenephrotoxicityrutinArticle30321822310.5152/turkjnephrol.2021.47312-s2.0-85112027400Q4455444WOS:000681656200005N/A