Dogramaci, Asena CigdemInan, Mehmet UgurAtik, EsinGokce, Cumali2024-09-182024-09-1820122146-31232146-3131https://doi.org/10.5152/balkanmedj.2011.027https://hdl.handle.net/20.500.12483/12150Scleredema is a rare connective tissue disorder that belongs to a group of scleroderma-like disorders. Although no known curative therapy exists, various specific treatments have been proposed in the literature. In this report, we describe five cases of scleredema partially treated with low-dose methotrexate therapy. All patients have diabetes mellitus type II. All patients were started on methotrexate 15 mg subcutaneously once weekly for 3 months. Biopsy specimens were taken from all patients and were examinated histologically before the treatment and after 3 months of treatment. All cases partially responded to low-dose methotrexate therapy. We believe that methotrexate therapy may be an alternative therapeutic options in scleredema in view of its efficacy.eninfo:eu-repo/semantics/openAccessScleredemalow-dose methotrexatediabetes mellitusEditorial Material29221822110.5152/balkanmedj.2011.027252070012-s2.0-84863094100Q1WOS:000315504700024Q4