Erayman, MustafaSandhu, DevinderSidhu, DeepakDilbirligi, MuharremBaenziger, P.S.Gill, Kulvinder S.2024-09-192024-09-1920040305-1048https://doi.org/10.1093/nar/gkh639https://hdl.handle.net/20.500.12483/15314By physically mapping 3025 loci including 252 phenotypically characterized genes and 17 quantitative trait loci (QTLs) relative to 334 deletion breakpoints, we localized the gene-containing fraction to 29% of the wheat genome present as 18 major and 30 minor gene-rich regions (GRRs). The GRRs varied both in gene number and density. The five largest GRRs physically spanning <3% of the genome contained 26% of the wheat genes. Approximate size of the GRRs ranged from 3 to 71 Mb. Recombination mainly occurred in the GRRs. Various GRRs varied as much as 128-fold for gene density and 140-fold for recombination rates. Except for a general suppression in 25-40% of the chromosomal region around centromeres, no correlation of recombination was observed with the gene density, the size, or chromosomal location of GRRs. More than 30% of the wheat genes are in recombination-poor regions thus are inaccessible to map-based cloning. © Oxford University Press 2004; all rights reserved.eninfo:eu-repo/semantics/openAccessChromosome MappingDNA, PlantGenes, PlantGenetic MarkersGenome, PlantPhenotypePhysical Chromosome MappingQuantitative Trait LociRecombination, GeneticTriticumTriticum aestivumplant DNAplant DNAarticlecentromerecontrolled studycorrelation analysisdensityDNA determinationgene deletiongene locationgene locusgene mappinggene numbergene repressiongenetic analysisgenetic recombinationmolecular cloningnonhumanphenotypeplant geneticspriority journalquantitative trait locus mappingrestriction fragment length polymorphismwheatchromosome mapgenegenetic markergeneticsgenomequantitative trait locuswheatArticle32123546356510.1093/nar/gkh639152408292-s2.0-3042848862Q1