Okuyucu, SemsettinAkoglu, ErtapBabayigit, CenkAkoglu, SebahatDagli, Safak2024-09-182024-09-1820091916-0216https://doi.org/10.2310/7070.2009.080193https://hdl.handle.net/20.500.12483/10773Objective: This study was performed to compare the effects of isotonic saline, hypertonic saline (buffered/nonbuffered), and lactated Ringer irrigation and distilled water nebulization on mucociliary clearance in ex vivo rats. Design: Experimental study. Setting: Tertiary otolaryngology care centre. Methods: Thirty rat tracheas were achieved from 15 rats by dividing the trachea longitudinally into two equal parts. Main Outcome Measures: Mucociliary transport velocity was measured by direct observation of particle placed on the lower end of the trachea after irrigation or nebulization. Results: Significant improvement in mucociliary clearance was found with isotonic saline (p = .002), buffered hypertonic saline (p = .018), lactated Ringer (p = .000), and nebulized distilled water (p = .000) when compared with nonbuffered hypertonic saline. Conclusion: Lactated Ringer solution is better than saline solution at enhancing mucociliary clearance, but nebulized distilled water is superior to the tested irrigation solutions in rat tracheal epithelium.eninfo:eu-repo/semantics/closedAccessirrigationlactated Ringer solutionmucociliary clearancenebulizationratsalinetracheaArticle38442242610.2310/7070.2009.080193197550812-s2.0-70349243237Q1WOS:000273634500002Q4