Serarslan, GamzeAtik, EsinOtlu, BarisBakaris, SevgiDurmaz, Riza2024-09-182024-09-1820071019-214X1308-6294https://hdl.handle.net/20.500.12483/10570Background and Design: This study was designed to investigate the role of proliferation markers in various benign, premalig- nant and malignant skin lesions and also aimed to detect HPV positivity in these lesions. Material and Method: A total of 62 paraffin blocks [12 seborrheic keratoses (SK), 10 keratoacantoma (KA), 8 actinic keratoses (AK), 22 basal cell carcinoma (BCC), and 10 squamous cell carcinoma (SCC)] were included in the study. Specimens were stud- ied immunohistochemically for the expression of Ki-67, p21 and bcl-2. PCR was performed to detect HPV DNA. Results: HPV positivity was detected in two tissues of BCC (HPV type-16). In the lesions, the Ki-67, p21 and bcl-2 expressions were found to be increased respectively: KAtrinfo:eu-repo/semantics/closedAccessHuman papilloma virusKi-67bcl-2p21Article4125762WOS:000217261600006N/A