Özcan, Erhan CahitÖzdemir, Hasan EmreGül, MehmetTanık, AbdulsametYıldırım, Tuba TaloBozoğlan, AlihanDündar, Serkan2024-09-192024-09-1920222146-1767https://doi.org/10.5577/intdentres.2022.vol12.no1.5https://search.trdizin.gov.tr/tr/yayin/detay/1123964https://hdl.handle.net/20.500.12483/16394Aim: Investigations into Ankaferd Blood Stopper® (ABS) on bone healing have revealed positive bone regeneration effects. The exact mechanism of this positive bone tissue metabolism effect is unknown. This study’s aim is a biomechanic and biochemical investigation of the effects of local ABS application on the osseointegration of titanium implants. Methodology: Sprague Dawley rats were divided into four groups of ten rats each. The control group (n=20) received no treatment during the experimental period, while the ABS group (n=20) had ABS applied locally during the surgical application of the titanium implant before insertion into the bone sockets. After 2 (controls n=10 and ABS n=10) and 4 weeks (controls n=10 and ABS n=10) experimental periods, the rats were sacrificed and implants with surrounding bone tissues were removed for reverse torque analysis (Newton), blood sample collection, and biochemical analysis. Results: The biomechanic bone implant contact ratio detected was higher in week 4 than in week 2 in the ABS group (p<0, 05). Lower phosphor levels were detected in the ABS group than in the 4-week controls (p<0, 05). Conclusion: According to the biomechanical parameters, ABS is more effective after four weeks than after two weeks when locally applied.eninfo:eu-repo/semantics/openAccessArticle121273310.5577/intdentres.2022.vol12.no1.51123964