Gokcek, IshakAydin, LeylaCellat, MustafaYavas, IlkerKutlu, Tuncer2024-09-182024-09-1820230798-2259https://doi.org/10.52973/rcfcv-e33288https://hdl.handle.net/20.500.12483/8843This study investigated the hormonal, inflammatory, oxidant-antioxidant, and histopathological effects of exogenous Melatonin administration on Spermatogenesis in rats' chronic unpredictable stress model (CUSM). In the study, stress caused a decrease in follicle stimulating-hormone (FSH), luteinizing hormone (LH), Testosterone, Melatonin, Glutathione (GSH), Glutathione peroxidase (GSH-Px), catalase, interleukin 10 (IL-10) levels and motility, and an increase in Corticosterone, nuclear factor kappa beta (NF-kB), tumor necrosis factor-alpha (TNF-alpha), interleukin 1 beta (IL-1 beta), interleukin 6 (IL-6), abnormal sperm, dead/live sperm ratio and exogenous Melatonin reduced inflammatory cytokines and oxidative stress and improved spermatological parameters (P<0.05). Melatonin also partially corrected stress-induced changes in testicular morphology. As a result, using Melatonin in rats with CUSM may be effective in improving spermatological parameters through anti-inflammatory and antioxidant mechanisms.eninfo:eu-repo/semantics/openAccessChronic stressspermatogenesisMelatoninantioxidantanti-inflammatory cytokinesArticle33210.52973/rcfcv-e332882-s2.0-85172866496Q4WOS:001069703500027Q4