Pinar, NeslihanKarapinar, Oya SoyluOzcan, OguzhanDogan, Esin AtikBayraktar, Suphi2024-09-182024-09-1820170008-42121205-7541https://doi.org/10.1139/cjpp-2016-0309https://hdl.handle.net/20.500.12483/11539The aim of this study was to investigate the antioxidant effects of tempol on ovarian ischemia-reperfusion (I/R) injury in rats. Forty female Wistar albino rats were randomly divided into 5 groups: Group I, sham; Group II, ischemia (I); Group III, I/R; Group IV, I/R + tempol 30 mg/kg i.p; Group V, I/R + tempol 50 mg/kg i.p. Oxidative stress index (OSI) was significantly higher in the ischemia group and the I/R group than in the sham group. Catalase levels were significantly lower in the I/R group than in the I/R + tempol 30 mg/kg i.p. and the I/R + tempol 50 mg/kg i.p. groups. Glutathione peroxidase levels were lower in the I/R group than in the I/R + tempol 30 mg/kg i.p. and the I/R + tempol 50 mg/kg i.p. groups. MDA levels were significantly lower in the I/R + tempol 30 mg/kg i.p. group and the I/R + tempol 50 mg/kg i.p. group than in the I/R group. The levels of the histopathological parameters were significantly decreased in the I/R + tempol 50 mg/kg i.p. group compared with the I/R group. Tempol can be used for reducing ovarian I/R injury.eninfo:eu-repo/semantics/openAccessovarian ischemia-reperfusiontempoloxidative stressArticle95786186510.1139/cjpp-2016-0309284232862-s2.0-85021841544Q3WOS:000404738500011Q3