Aydin, A. Ebru2024-09-182024-09-1820130268-26051099-0739https://doi.org/10.1002/aoc.2969https://hdl.handle.net/20.500.12483/9771Novel chiral thiolated amino alcohols were synthesized from norephedrine and thiophene carbaldehydes (methyl- or ethyl-substituted) and applied to the catalytic asymmetric Henry reaction of various aldehydes with nitromethane to provide -hydroxy nitroalkanols in high conversion (92%). The reaction was optimized in terms of the metal, solvent, temperature and amount of chiral ligand. The corresponding catalyst with Cu(OTf)2 and 2-propanol as the solvent provided the best enantioselectivities (up to 96% ee) of the corresponding nitroalcohols for aliphatic aldehydes. Copyright (c) 2013 John Wiley & Sons, Ltd.eninfo:eu-repo/semantics/closedAccessenantioselective synthesisHenry reactionchiral amino alcoholsthiolated amino alcoholscopper complexArticle27528328910.1002/aoc.29692-s2.0-84876688210Q1WOS:000318116900005Q2