Dogan, Esra Sinem KemerDuran, Nizami2024-09-182024-09-1820221432-69811436-3771https://doi.org/10.1007/s00784-022-04502-0https://hdl.handle.net/20.500.12483/7407Objectives The aim of this study was to evaluate the levels of salivary and serum interleukin (IL)-1 beta, visfatin, and omentin-1 in the relationship between periodontal disease and overweight/obesity as well as to reveal the possible role of periodontal inflamed surface area (PISA) in this association. Materials and methods Ninety-six individuals (69 females, 27 males) were divided into 4 groups as systemically healthy (H) and non-periodontitis (HnP, n=23), systemically healthy and periodontitis (HP, n= 24), overweight/obese (O) and nonperiodontitis (OnP, n=25), and overweight/obese and periodontitis (OP, n =24). Periodontal parameters were measured, and PISA was calculated. IL-1 beta, visfatin, and omentin-1 levels in saliva and serum samples were analysed. Results Periodontal parameters deteriorated, salivary and serum IL-1 beta and visfatin levels were increased, and omentin-1 levels were decreased in OnP and OP groups, compared to HnP and HP groups. Salivary and serum IL-1 beta and visfatin levels were increased and omentin-1 levels were decreased in periodontitis groups, compared to HnP and OnP groups. PISA was negatively correlated with salivary omentin-1 and positively correlated with salivary and serum visfatin in H and O groups, whereas a positive relationship was found between PISA and salivary and serum IL-1 beta in H group. Conclusions PISA may be negatively associated with salivary omentin-1, while positively correlated with salivary and serum visfatin in overweight/obese patients.eninfo:eu-repo/semantics/closedAccessAdipokinesObesityOverweightPeriodontal diseasesArticle2685351535810.1007/s00784-022-04502-0354516542-s2.0-85128776736Q1WOS:000785592800004Q2