Cabalak, MehmetBal, TayibeOnlen, YusufDemir, Mehmet2024-09-182024-09-1820200049-47551758-1133https://doi.org/10.1177/0049475519892082https://hdl.handle.net/20.500.12483/8821Evaluation of the incidence and predictors of failure of direct-acting antiviral treatment for hepatitis C virus genotype 1b patients is important. Our retrospective cohort study assessed 172 Turkish patients who had received a full course of such treatment and could be checked for sustained virologic response. The overall treatment failure rate was 2.9% (5/172), all of whom relapsed. In three of these cases with sequencing data available, all had NS5A resistance-associated substitution. Multivariate analysis revealed that a 1 mg/dL increase in pre-treatment total bilirubin level was associated with a sevenfold increased likelihood of treatment failure. The baseline level of total bilirubin was the only significant independent predictor of direct-acting antiviral treatment failure.eninfo:eu-repo/semantics/closedAccessChronic hepatitis C virus infectiondirect-acting antiviralsgenotype 1binterferon-freesustained virologic responseArticle50214114610.1177/0049475519892082318104152-s2.0-85077379257Q3WOS:000501134200001Q4