Akoglu, ErtapGoeruer, SadikAtik, EsinOkuyucu, SemsettinSanguen, Oezlem2024-09-182024-09-1820060165-5876https://doi.org/10.1016/j.ijporl.2006.06.019https://hdl.handle.net/20.500.12483/11379Objective: To determine any possible adverse effect of 1-deamino 8-D-arginine vasopressin (DDAVP) spray on nasal cytology and mucociliary clearance in patients with nocturnal enuresis. Methods: Twenty-two children aged 6-16 enrolled in the study. Epithelial surface cells samples were taken from the nasal mucosa and mucociliary clearance time was calculated before and 1 and 6 months after administration of DDAVP spray. Results: No qualitative changes in the epithelial surface cells and mucociliary clearance time were observed at 1 and 6 months after therapy. Conclusion: Based on the findings of the present study, DDAVP spray can be used for 6 months in children without apparent risk of damage to the epithelial surface cells and mucociliary clearance time. (C) 2006 Elsevier Ireland Ltd. Atl. rights reserved.eninfo:eu-repo/semantics/closedAccessnocturnal enuresisDDAVP sprayvasopressinnasal mucosanocturnal enuresisArticle70111919192210.1016/j.ijporl.2006.06.019169015502-s2.0-33749571008Q2WOS:000241932800011Q3