Pınar, NeslihanÖzcan, OğuzhanDoğan, EsinÇakırca, Gökhan2020-07-232020-07-232019Pinar, N., Ozcan, O., Dogan, E., & Cakirca, G. (2019). Protective effect of dexpanthenol on gentamicin-induced nephrotoxicity in rats. Annals of Medical Research, 26(9), 1787-91.2636-7688https://dx.doi.org/10.5455/annalsmedres.2019.07.435https://hdl.handle.net/20.500.12483/2925Aim: We evaluated the protective effects of dexpanthenol (Dxp) in rats with gentamicin (Genta)-induced nephrotoxicity by assessing a panel of biochemical and histopathologic parameters. Material Methods: Forty rats were divided randomly into the following four groups: Control group, physiological saline solution (0.5 cc intraperitoneally (i.p.) for 8 days; Dxp group, Dxp (500 mg/kg i.p.) for 8 days; Genta group, Genta (100 mg/kg, i.p.) for 8 days; and Genta+Dxp group, Gent a and Dxp (100 and 500 mg/kg i.p., respectively) for 8 days. Results: TIn the Genta group, the urea, creatinine, tumor necrosis factor-alpha (TNF-α), total oxidant status (TOS), oxidative stress index (OSI) and malondialdehyde (MDA) levels were significantly higher and the catalase (CAT) and glutathione peroxidase (GSH-Px) activities were significantly lower than those in the control group. In the Genta+Dxp group, the urea, creatinine, and TNF-α, TOS, OSI and MDA levels were significantly lower and the CAT and GSH-Px activities were significantly higher than those in the Genta group. Histopathological investigation showed severe tubular necrosis in the Genta group, which was of lesser severity in the Genta+Dxp group. Conclusion: The biochemical and histopathologic results of this study indicate that Dxp can ameliorate Genta-induced nephrotoxicityeninfo:eu-repo/semantics/openAccessOxidative stressAntioxidantGentamicinNephrotoxicityDexpanthenolArticle2691787179110.5455/annalsmedres.2019.07.435318146