Ocak, SabahattinGorur, SadikHakverdi, SibelCelik, SefaErdogan, Suat2024-09-182024-09-1820071742-78351742-7843https://doi.org/10.1111/j.1742-7843.2007.00051.xhttps://hdl.handle.net/20.500.12483/13521The objective of this study was to compare the beneficial effects of caffeic acid phenethyl ester (CAPE), vitamin C, vitamin E and N-acetylcysteine on vancomycin-induced nephrotoxicity. Thirty rats were randomly devided into six groups: (i) control; (ii) vancomycin, 200 mg/kg administrated via intraperitoneal route; (iii) vancomycin plus CAPE - vancomycin with 10 mu mol/kg CAPE; (iv) vancomycin plus vitamin C - vancomycin (intraperitoneally) with 200 mg/dl vitamin C in drinking water; (iv) vancomycin plus vitamin E - vancomycin with 1000 mg/kg body weight vitamin E (intramuscularly); and (vi) vancomycin plus N-acetylcysteine - vancomycin with 10 mg/kg body weight (intraperitoneally) of N-acetylcysteine. Vancomycin treatments were started I day after the first administrations of these agents and continued for 7 days. At the end of the experiments, catalase activity was significantly decreased by vancomycin in kidney homogenates (P < 0.05). Vitamin E, vitamin C, N-acetylcysteine and CAPE administrations decreased the blood urea nitrogen levels increased by vancomycin, although significant differences were detected only in the vitamins E and C groups (P < 0.05). Increased renal malondialdehyde and nitric oxide levels by vancomycin were significantly suppressed by agents used in the study (P < 0.05). Histopathological examination demonstrated prominent damages in the vancomycin-treated group. Vitamin E was the most beneficial agent on vancomycin-induced tubular damage, followed by vitamin C, N-acetyleysteine and CAPE treatments, respectively. The data suggest that vitamin E, as well as vitamin C, N-acetyleysteine and CAPE, could be useful for reducing the detrimental effects on vancomycin-induced toxicity in kidneys.eninfo:eu-repo/semantics/openAccessGentamicin-Induced NephrotoxicityTargeting Superoxide-DismutaseProximal Tubule CellsOxidative StressNitric-OxideLipid-PeroxidationRenal ToxicityCisplatinSerumSupplementationArticle100532833310.1111/j.1742-7843.2007.00051.x174481192-s2.0-34247324695Q2WOS:000246449300007Q3