Serarslan, GAtik, E2024-09-182024-09-1820050300-8177https://doi.org/10.1007/s11010-005-8542-3https://hdl.handle.net/20.500.12483/9319Cutaneous leishmaniasis (CL) is an infectious disease caused by Leishmania parasite. The expression of inducible nitric oxide synthase (iNOS) and generation of nitric oxide in response to IFN-gamma and TNF-alpha is important in control of infection. The aim of the study was to determine the expression of iNOS in the lesions of Leishmania tropica, and whether there was a correlation between the level of expression and the duration of the disease. Punch biopsy was performed from patients (n = 29) and iNOS immunohistochemical staining was applied. Expression of iNOS protein was detected 82.8% of patients. There was a strong expression with the duration of the disease less than 6 months (p < 0.002). These findings demonstrate that iNOS has a role in L. tropica especially during the early stages of the infection.eninfo:eu-repo/semantics/closedAccesscutaneous leishmaniasisinducible nitric oxide synthaseLeishmania tropicanitric oxideArticle2801-214714910.1007/s11010-005-8542-3163119162-s2.0-29244470538Q1WOS:000233547300018Q3