Altas, M.Meydan, S.Aras, M.Yilmaz, N.Ulutas, K. T.Okuyan, H. M.Nacar, A.2024-09-182024-09-1820130967-58681532-2653https://doi.org/10.1016/j.jocn.2012.05.030https://hdl.handle.net/20.500.12483/8348The aim of this study was to investigate the effect of ceftriaxone treatment against short-term global brain ischemia/reperfusion (I/R) injury in rats. The study was carried out on 30 Wistar-albino rats that were divided into three groups: control group (n = 10), I/R group (n = 10) and I/R-ceftriaxone group (n = 10). Malondialdehyde (MDA) levels were significantly increased in the I/R group in comparison with the control group (p < 0.001). MDA was significantly lower in the I/R-ceftriaxone group than in the I/R group (p < 0.05). Superoxide dismutase activity was significantly decreased in the I/R group and increased in the I/R-ceftriaxone group as compared with the control group. Glutathione peroxidase activity was significantly decreased in the I/R group and increased in the I/R-ceftriaxone group as compared with the I/R group and the control. Histopathologically, ceftriaxone provided morphological improvement compared with the I/R group. We concluded that ceftriaxone has neuron-protective effects due to its antioxidant properties as shown by a decrease in MDA overproduction and histological improvement in brain tissue. (C) 2012 Elsevier Ltd. All rights reserved.eninfo:eu-repo/semantics/closedAccessBrainCeftriaxoneIschemiaArticle20345746110.1016/j.jocn.2012.05.030232198252-s2.0-84875226790Q1WOS:000316839900025Q4