Tuzcu, Esra AyhanTuzcu, KasimBasarslan, FatmagulMotor, SedatCoskun, MesutKeskin, UgurcanAyintap, Emre2024-09-182024-09-1820141556-95271556-9535https://doi.org/10.3109/15569527.2013.857679https://hdl.handle.net/20.500.12483/8619Objective: To examine the relationship of cataract forming effect of intravitreal triamcinolone acetonide (IVTA) injection with oxidative status and the effect of N-acetylcysteine (NAC) on these alterations. Materials and methods: Twenty-six Wistar-Albino rats were included in the study. Rats were assigned into four groups as follows: intravitreal saline injection group (controls); IVTA injection group; IVTA + intraperitoneal NAC injection group (IVTA + NAC); and intraperitoneal NAC injection group (NAC). Triamcinolone acetonide was intravitreally injected at a dose of 1 mg. NAC was intraperitoneally injected at a dose of 150 mg/g body weight. Animals were sacrificed and lens specimens were analyzed for levels of malondialdehyde (MDA) and protein carbonyl (PC) and activities of glutathione (GSH) and glutathione peroxidase (GSH-Px). Results: We found that the MDA and PC levels of lenses were increased in the IVTA group (p < 0.01). It was seen that GSH and GSH-Px in lenses were decreased in the IVTA group (p < 0.01). NAC administration significantly ameliorated these changes in the IVTA + NAC group (p<0.05). Conclusion: These results indicate that the NAC produces a protective mechanism against IVTA-induced cataract and suggest a role of oxidative stress in pathogenesis.eninfo:eu-repo/semantics/closedAccessCataractintravitreal triamcinolone acetonide injectionN-acetylcysteineoxidative statusArticle33429429810.3109/15569527.2013.857679246411122-s2.0-84912082270Q3WOS:000345498400006Q3