Kurt, Raziye KeskinDogan, Ayse CitilDogan, MuratAlbayrak, AynurKurt, Sefika NurEren, FurkanSilfeler, Dilek Benk2024-09-182024-09-1820151341-80761447-0756https://doi.org/10.1111/jog.12658https://hdl.handle.net/20.500.12483/7830AimThe aim of the study was to investigate the effectiveness of zofenopril in an experimental model of ovarian torsion in rats with histologic and biochemical assessments. Material and MethodsExperimental procedures were performed on 35 female rats (Wistar albino). Rats were randomly divided into five groups as: sham (sham operated, n=7); vehicle group 1 (torsion-detorsion, n=7) with 2h ischemia and 2h reperfusion; vehicle group 2 (torsion-detorsion, n=7) with 2h ischemia and 5 days' reperfusion; zofenopril group 1 (torsion-detorsion, n=7) with 2h ischemia, 2h reperfusion and a signal dose of oral 15mg/kg zofenopril; and zofenopril group 2 (torsion-detorsion, n=7) with 2h ischemia, 5 days' reperfusion and 5 days' oral 15mg/kg zofenopril. A scoring of histopathologic evaluation was performed on the ovaries according to congestion, bleeding, edema, and cellular degeneration. Biochemical assessments included catalase, tissue malondialdehyde and protein carbonyl. ResultsCompared with the vehicle groups, histopathologic scores, tissue malondialdehyde and protein carbonyl levels, which reflect oxidative stress markers, were significantly lower in the zofenopril groups. Furthermore, catalase levels were significantly increased in the zofenopril group. ConclusionOur study results revealed that zofenopril attenuates injury induced by ischemia-reperfusion on rat ovary.eninfo:eu-repo/semantics/closedAccessantioxidantischemia-reperfusion injuryovarian torsionzofenoprilArticle41692693110.1111/jog.12658255463782-s2.0-84930335022Q2WOS:000355743000014Q4