Investigation of apoptotic effects of hypericum perforatum extract on breast cancer cell line
Accessinfo:eu-repo/semantics/openAccessAttribution-NonCommercial 3.0 United Stateshttp://creativecommons.org/licenses/by-nc/3.0/us/
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CitationHarun, A. L. P., TUTUN, H., KAPLAN, H. M., ŞİNGİRİK, E., & ALTINTAŞ, L. (2019). Investigation of Apoptotic Effects of Hypericum perforatum Extract on Breast Cancer Cell Line. Harran Üniversitesi Veteriner Fakültesi Dergisi, 8(2), 198-202.
Abstract: Hypericum perforatum has biological active contents affecting a variety of proteins such as caspase-3, bcl-2, and bax, which mediate apoptosis known as programmed cell death and exerting anti-inflammatory effect. Apoptotic pathways are important for cancers, chemotherapeutic resistance, and cancer development. Anti-inflammatory agents are also a potential target for cancer. Therefore, it was aimed to investigate the activity of caspase-3 and the expressions of bcl-2, bax, wee 1, gadd153, grp78, AIF, iNOS, COX-2, cPLA2, and NF-κB in H. perforatum extract-treated breast cancer (BC) cells in this study. The activity of caspase-3 and the expressions of these proteins were determined in the cells by ELISA. The HP extract increased the activity of caspase-3 and the expressions of bax, wee 1, gadd153, grp78 and AIF, and decreased the expressions of bcl-2, COX-2, iNOS, cPLA2 and NF-κB in the BC cells. In the light of these findings, HP extract could help to inhibit grow of BC cells and its anti-inflammatory effect may contribute this effect.
SourceHarran Üniversitesi Veteriner Fakültesi Dergisi
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