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    Investigation of mean platelet volume in people with chronic hepatitis C virus infection
    (Turkiye Klinikleri, 2013) Köksaldi Motor, Vicdan; Evirgen, Ömer; Önlen, Yusuf; Yula, Erkan; Büyükkaya, Eyüp; Çelik, M. Murat; Yengil, Erhan
    Objective: The mean platelet volume is a parameter routinely determined by complete blood count analyzer, and it is correlates with platelet function and activation. Platelet activation and aggregation play an important role in the pathophysiology of atherosclerosis. The mean platelet volume, which is a marker of platelet activation, is considered as a risk factor for atherothrombosis. Especially in recent years, many studies investigating the relationship between hepatitis C virus and atherosclerosis is noteworthy. The aim of the present study was to investigate mean platelet volume in people with chronic hepatitis C virus infection. Material and Methods: The patient group was constituted by 141 patients followed up due to chronic hepatitis C virus infection, while 107 healthy subjects acted as the control group. The data of patients with chronic hepatitis C virus infection and the control group were analyzed retrospectively. Results: The patients with chronic hepatitis C virus infection had a mean age of 53.5±12, 57 years, there were 57 (40.4%) males and 84 (59.6%) females. In the control group, there were 40 (37.4%) males and 67 (62.6%) females, and mean age was calculated as 53.2±12.8 years. While the platelet count was decreased in subjects with chronic hepatitis C virus infection, the mean platelet volume was increased. Conclusion: It was observed that mean platelet volume levels were not affected by the patient's genotype, RNA and alanine aminotransferase levels. The mean platelet volume was significantly higher in patients with chronic hepatitis C virus infection and this supported other investigations that established a connection between hepatitis C virus infection and the risk of atherothrombosis. © 2013 by Türkiye Klinikleri.