Yazar "Çelik, S" seçeneğine göre listele

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    Öğe
    The effect of genotype on the antioxidative metabolism in Angora goats
    (Scientific Technical Research Council Turkey, 2001) Fidanci, UR; Turgay, F; Zengin, S; Kargin, F; Çelik, S; Tasdemir, U
    In this study, lipid peroxidation, intracellular, membrane and extracellular antioxidant activities in Turkish Angora goats (Genotype I) and American x Turkish crossbred Angora goats (Genotype II) were investigated. in order to show the effects of genotype on the antioxidative metabolism. Plasma malonlydialdehyde (MDA) levels of Angora goats in different genotype were analyzed to show the effects of free radicals. Glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT) activities in hemolysates of erythrocytes were analyzed as intracellular antioxidants, beta -carotene in serum as membrane antioxidants and ascorbic acid in plasma, albumin, total bill glucose, uric acid and ceruloplasmine in serum as extracellular antioxidants to determine the change in the antioxidative metabolism. Plasma MDA levels in American x Turkish crossbred Angora goats (Genotype II) were found to be significantly higher than the plasma MDA levels in Turkish Angora goats (Genotype I) (p less than or equal to 0.05). Erythrocyte GSH-Px and SOD activities in American x Turkish crossbred Angora goats (Genotype II) were found to be significantly lower than the erythrocyte GSH-Px and SOD activities in Turkish Angora goats (Genotype I) (p less than or equal to 0.001). However, activities of CAT in Turkish x American crossbred Angora goats (Genotype II) were found to be significantly higher than the activities of CAT in Turkish Angora goats (p less than or equal to 0.01). There were no statistically significant differences between the serum li-carotene, plasma ascorbic acid, serum albumin, bilirubin and glucose levels of Angora goats in different genotypes (p greater than or equal to 0.05). Significant decreases were found both in serum uric acid (p less than or equal to 0.001) and ceruloplasmin (p less than or equal to 0.05) levels of Angora goats in genotype II. It was concluded that improving the productivity by genotypical variation in animal breeding may affect the antioxidative metabolism. The increasing peroxidative metabolism in American x Turkish crossbred Angora goats affected the intracellular antioxidants of the antioxidative metabolism. However, extracellular antioxidant responses were limited to the increasing peroxidative metabolism in genotype II. These findings showed that extracellular and membrane antioxidants are secondary antioxidants.
  • [ N/A ]
    Öğe
    Evaluation of dogs with colitis and ulcerative colitis using radiographic, electrocardiographic and laboratory findings
    (Scientific Technical Research Council Turkey, 2003) Durgut, R; Çelik, S; Öztürk, S; Pekkaya, S
    Sixteen dogs with suspected colitis and ulcerative colitis were examined by clinical, radiographic, laboratory and electrocardiographic means from a diagnostic perspective. In the history and clinical examination, mild diarrheic feces mixed with uncoagulated blood and mucus were determined in all dogs. Tenesmus after defecation, mild weight loss and anemia were common observations. Abdominal palpation revealed a palpable thickened large intestine. Biochemical analyses of blood serums showed that potassium levels were increased, and sodium and total protein levels were decreased. A contrast radiographic examination showed that colon walls were thickened; stenosis, dilatation and shortening of the colons had occurred; and the normal shape of the colons had changed. In microbiologic investigations, in eight dogs' feces, Campylobacter spp., Salmonella spp., Clostridium perfringens and Escherichia coli were isolated. In electrocardiograms, there were typically large peaked T waves in all dogs and flattened P waves in only two dogs. P-R and Q-T intervals were prolonged in four dogs and in only one dog widened QRS and bradycardia were present. In conclusion, it is important to evaluate the clinical signs with radiologic, electrocardiographic and laboratory findings when diagnosing colitis and ulcerative colitis in dogs.