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  • Küçük Resim
    Öğe
    Immunostimulatory effects of Aloe vera and ?-Glucan on cellular and humoral immune responses following vaccination with polyvalent vaccines in dogs
    (2010) Altuğ, Nuri; Yüksek, Nazmi; Ağaoğlu, Zahid Tevfik
    The aim of this study was to evaluate the effects of Aloe vera and β-Glucan on lymphocyte subsets, haematological parameters and immunglobulin concentrations following vaccination in dogs. For this purpose, totally 20 street dogs were used. The animals were allocated into five groups. Group 1 consisted of only polyvalent vaccine applied dogs. Group 2 and 3 were only Aloe vera and β-Glucan applied dogs, respectively. Group 4 and 5 were consisted of polyvalent vaccine in addition to Aloe vera and β-Glucan applied dogs, respectively. Blood samples were collected before vaccination and after vaccination (AV). Although platelet (PLT) counts in group 1 decreased AV, in all other groups (group 2, 3, 4, 5) it increased. White blood cell (WBC) and peripheral blood mononuclear lymphocyte (PBML) counts (in all groups), peripheral blood polymorphonuclear lymphocyte (PBPL) counts (group 1, 2, 4, 5), neutrophil (group 1, 4, 5), monocyte (group 2, 3, 5), packed cell volume (PCV) ratios (group 2 and 3) and haemoglobin (HGB) concentrations (group 3) increased AV. But, lymphocyte ratios in all groups did not change AV. CD8 T lymphocyte ratios in all groups increased at $7^{th}$ and $14^{th}$ days AV. Although CD3 T lymphocyte ratios in group 1 increased at $7^{th}$ day AV, CD4 T and B lymphocytes ratios did not change AV period. But, both CD3 and CD4 T lymphocytes ratios in all other groups increased at $7^{th}$ and $14^{th}$ days AV. Moreover, B lymphocytes ratios in all groups except for group 1 increased AV. On the other hand, B lymphocytes ratios in group 2 and 3 increased only $7^{th}$ day AV, while this increase in group 4 and 5 were present on both $7^{th}$ and $14^{th}$ days AV. Serum IgM concentrations in group 1 increased only $7^{th}$ day AV, whereas its levels did not change in group 2 and 3. Serum IgG concentrations in group 1, 2 and 3 increased only $14^{th}$ day AV. But, serum IgM and IgG concentrations in group 4 and 5 increased at $7^{th}$ and $14^{th}$ days AV. Administration of Aloe vera and β-Glucan after vaccination in dogs may stimulate both cellular and humoral immun responses. Additionally, it might have restorative effect on PLT counts.
  • Küçük Resim
    Öğe
    Sivas İlindeki Köpeklerde Cryptosporidium Spp.’nin Prevalansı
    (2022) Ağaoğlu, Zahid Tevfik; Başbuğ, Onur; Özpınar, Necati
    Cryptosporidium spp. zoonotik özelliğe sahip, insan ve hayvanların gastrointestinal sisteminde hastalık olu?turan bir protozoondur. Bu çalı?ma, Sivas ilindeki farklı ya? aralığındaki köpeklerde, farklı metotlarla Cryptosporidium spp. prevalansını belirlemek amacıyla yapıldı. Bu çalı?manın materyalini farklı ırk, ya? ve cinsiyetten 100 adet köpek olu?turdu. Çalı?maya dâhil edilen köpeklerin i?tah durumu, vücut sıcaklığı, kalp atım sayısı, solunum sayısı, solunum tipi, kapiller dolum zamanı, dehidrasyon oranı, mukoza muayenesi ve mental durumları muayenelerinde anormal bir durum gözlenmedi. Hayvanlardan dı?kı örnekleri plastik kaplara alındı. Toplanan dı?kı örneklerinde Cryptosporidium spp. ookistlerinin saptanması amacıyla direkt inceleme, asit-fast boyama ve Polimeraz Zincir Reaksiyon (PZR) yöntemi kullanıldı. ?ncelenen dı?kı örneklerinde pozitiflik oranı direkt incelemede %0, asit-fast boyamada %2 ve PZR testinde ise %4 olarak belirlendi. Sonuç olarak, bu çalı?mada Sivas ilinde Cryptosporidium spp. pozitiflik oranı hayvan hastanesine kontrol amacıyla getirilen köpeklerde %0, barınak köpeklerinde %8 olduğu belirlendi. Ayrıca 1 ya?ın altı, 1-5 ya? ile 6 ya? üstündeki barınak köpeklerinde sırası ile %13.3, %5.8 ve %5.5 oranında pozitiflik saptandı