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Öğe Assessment of Sensitivity to the Anesthesia in a Diabetic Rat Model(Wiley-Blackwell, 2015) Dokuyucu, Recep; Dogan, Hatice; Agturk, Gokhan; Cay, Emrah; Bilgic, Yasemin; Egeli, Duygu; Tutuk, Okan[Abstract Not Available]Öğe Disinfectant Effect of Thyme Oil in Diabetic Wound Model(Wiley-Blackwell, 2015) Temel, Metin; Dokuyucu, Recep; Gokce, Hasan; Agturk, Gokhan; Dogan, Hatice[Abstract Not Available]Öğe The Effect of Thymoquinone in Hepatic Ischemia/Reperfusion Rat Model(Wiley-Blackwell, 2015) Caglar, Kerem; Gokce, Hasan; Ozcan, Oguzhan; Tas, Zeynel Abidin; Dogan, Hatice; Agturk, Gokhan; Sefil, Fatih[Abstract Not Available]Öğe Effect of thymoquinone on transient receptor potential melastatin (TRPM) channels in rats with liver ischemia reperfusion model in rats(Mashhad Univ Med Sciences, 2024) Caglar, Kerem; Dokuyucu, Recep; Agturk, Gokhan; Tumer, Cemil; Tutuk, Okan; Gocmen, Hatice Dogan; Gokce, HasanObjective(s): We aimed to investigate the levels of transient receptor potential melastatin (TRPM) gene expression, and the antioxidant and histopathologic effect of thymoquinone (Tmq) in the hepatic I/R rat model. Materials and Methods: Fifty Wistar rats were divided into 5 groups. Group 1: Control; Group 2: Sham; Group 3: Hepatic I/R (45 min/45 min); Group 4: Tmq (50 mg/kg); Group 5: Tmq+I/R (ten days before I/R at the dose of 50 mg/kg of Tmq). The hepatic I/R (45min/45min) model was performed at the portal vein and the hepatic artery with atraumatic vascular clamp in the ischemia groups. The liver tissues and blood samples that were taken at the end of the study were evaluated for histopathologic and biochemical analysis. Besides TRPM gene expression levels were determined in liver tissues. It was seen that cellular swelling, congestion, PNL, and apoptosis parameters statistically decreased in Tmq and Tmq+I/R groups in comparison with the I/R group in histopathological evaluation. Results: It was observed that biochemical parameters, AST, ALT, GGT, LDH, creatinine, and urea levels significantly increased in the I/R group as compared with, sham, Tmq, and Tmq+I/R groups. It was found that TRPM2,6,7,8 gene expression decreased significantly in Tmq+I/R groups as compared to the I/R group. Conclusion: We showed that thymoquinone can inhibit the entry of Ca+2 into the cell by decreasing TRPM2,6,7,8 gene expression. Based on our findings, we think that Tmq application in the treatment of liver diseases due to I/R damage may be important in terms of both ischemia and apoptosis and can also be used in the treatment of liver-related diseases.Öğe The Effect of Vitamin D in an Experimental Varicocele Model(Wiley, 2018) Agturk, Gokhan; Demir, Enver Ahmet; Tutuk, Okan; Dogan, Hatice; Ozgur, Tumay; Tumer, Cemil[Abstract Not Available]Öğe Effect of vitamin D in experimental varicocele model in rats(Cukurova Univ, Fac Medicine, 2024) Agturk, Gokhan; Tumer, Cemil; Tutuk, Okan; Gocmen, Hatice Dogan; Ozgur, Tumay; Ozcan, Oguzhan; Duran, Gulay GulbolPurpose: Varicocele is a pathological condition that affects approximately 20% of adult men, causing infertility and sperm deterioration. The aim of our study was to investigate the efficacy of vitamin D (Vit. D) in the pathophysiology of varicocele. We performed biochemical, gene expression analyses and histopathological to evaluate the efficacy of vitamin D in the experimental varicocele model. Materials and Methods: In the study, 30 adult male Wistar Albino rats were used. The rats were divided into 3 groups equally as control group, experimental group (varicocele), treatment group (varicocele + D vit.). The treatment group received 500 IU/kg D vit. intramuscularly. Results: Histopathological, TRPM2-8 gene expression and biochemical analyses were performed on testicular and blood samples collected at the end of the experiment. The experimental group showed a deterioration in tubular structure, a decrease in total antioxidant levels and an increase in total oxidant levels. The treatment group, on the other hand, showed an increase in TAS, a decrease in TOS and a beneficial improvement in tubular structure disorders. Analysis of gene expression levels showed that TRPM2-8 expression levels were significantly increased in the varicocele group and decreased in the treatment group. Conclusion: In the varicocele model, the use of vitamin D had a significant effect on TRPM2-8 gene level, pathological seminiferous tubules and biochemical values. Further studies are needed to determine the clinical application of vitamin D in varicocele disease.Öğe Histopathological Effects of Erdosteine in Rat Hepatic Ischemia/Reperfusion Model(Wiley-Blackwell, 2015) Tutuk, Okan; Dokuyucu, Recep; Gokce, Hasan; Ozcan, Oguzhan; Tas, Zeynel Abidin; Dogan, Hatice; Agturk, Gokhan[Abstract Not Available]Öğe Investigation of Therapeutic Effects of Erdosteine on Polycystic Ovary Syndrome in a Rat Model(Karger, 2018) Karateke, Atilla; Dokuyucu, Recep; Dogan, Hatice; Ozgur, Tumay; Tas, Zeynel Abidin; Tutuk, Okan; Agturk, GokhanObjective: Polycystic ovary syndrome (PCOS) is a serious endocrine disorder. In the present study, we investigated the therapeutic effects of erdosteine in letrozole-induced PCOS in rats. Methods: Thirty-two Wistar albino female rats were grouped as control group (C), PCOS group (PCOS), PCOS-metformin group (PCOS+MET), and PCOS-erdosteine group (PCOS+Erd). PCOS was induced by administering letrozole; such rats presented with sex hormone disorder, abnormal estrous cycles determined by daily vaginal smear, large cystic follicles, and increasing fasting insulin levels. After induction of PCOS, metformin (500 mg/kg/day) and erdosteine (100 mg/kg/day) were given orally to the treatment groups for 30 days. Serum concentrations of glucose, total cholesterol, low-and high-density lipoprotein, triglyceride, as well as the total oxidant and antioxidant status, oxidative stress index, circulating estrone (E1), estradiol (E2), testosterone, and androstenedione were evaluated. The ovaries were graded histologically. Results: Weights of ovarian tissues (p < 0.05) and the number of atretic follicles (p < 0.001) and cystic follicles (p < 0.01) decreased in the PCOS+Erd group; the corpus luteum number was significantly higher in the PCOS+Erd group (p < 0.01) as compared with the PCOS group. Lipid parameters (total-C, LDL-C, and TG), E1 (estrone), E1/E2 ratio, testosterone, and androstenedione significantly decreased, while HDL-C and E2 (estradiol) significantly increased in the PCOS+Erd group as compared with the PCOS group. Moreover glucose, insulin, and HOMA-IR were reduced with treatment of erdosteine (p > 0.05, p < 0.001, and p < 0.001, respectively). Conclusion: It is suggested that erdosteine may be used in the treatment of PCOS as an alternative to metformin. It appears that our findings might be supported by clinical and molecular studies. (c) 2018 The Author(s) Published by S. Karger AG, BaselÖğe Multifunctional hernia repair biopatch: Development, characterization, in vitro and in vivo evaluation(Editions de Sante, 2024) Deveci, Mehmet Zeki Yilmaz; Enguven, Gozde; Ege, Hasan; Alakus, Ibrahim; Agturk, Gokhan; Yontem, Fulya Dal; Yilmaz, SenanurIncisional hernia, a prevalent postoperative complication, is characterized by the protrusion of organs or tissues through damaged abdominal wall. Predisposing factors for hernias include obesity, wound infections, immunosuppression, and comorbidities. However, hernia patches currently in use, including the commercial polypropylene (PP) patch, still have limitations in providing the mechanical and biological properties necessary for abdominal wall regeneration. In this study, three dimensional (3D) printing and coaxial electrospinning methods were combined to create a multifunctional double layered hernia repair biopatch to overcome these limitations. The double-layer design of the biopatch serves a multifunctional role in addressing incisional hernia models, with 3D printed ciprofloxacin (CIP) loaded polycaprolactone (PCL)/gelatin (Ge) scaffold (3DCIP) layer and coaxially electrospun PCL/Ge/?-carrageenan (?-C) nanofiber (NF) layers. While 3DCIP layers provides temporary mechanical reinforcement to the damaged abdominal wall, prevention of adhesions to internal organs, and reduction of surgical site infections, NF layer serves as tissue regeneration and fast wound healing. The developed multifunctional hernia biopatches underwent comprehensive physical and chemical characterization, followed by in vitro and in vivo evaluations. These evaluations included comparisons with a commercial PP patch, which was used as the control in the experiments. The study successfully fabricated multifunctional hernia biopatches with excellent antibacterial properties, high mechanical robustness, and strong biocompatibility. © 2024 Elsevier B.V.Öğe The Therapeutic Effects of Erdosteine in a Rat Model of Polycystic Ovary Syndrome(Wiley-Blackwell, 2015) Dokuyucu, Recep; Ozgur, Tumay; Tas, Zeynel Abidin; Tutuk, Okan; Dogan, Hatice; Agturk, Gokhan[Abstract Not Available]Öğe Therapeutic Effects of Thymoquinone and Peanut Oil in an Infected Diabetic Wound Model(Wiley-Blackwell, 2015) Dokuyucu, Recep; Temel, Metin; Gokce, Hasan; Dogan, Hatice; Agturk, Gokhan; Akdag, Abdurrahman; Tutuk, Okan[Abstract Not Available]Öğe Wound Healing Effect of Centaury Oil Treatment in Diabetic Wound Model(Wiley-Blackwell, 2015) Temel, Metin; Dokuyucu, Recep; Gokce, Hasan; Tas, Zeynel Abidin; Tutuk, Okan; Dogan, Hatice; Agturk, Gokhan[Abstract Not Available]
