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    Gradual detorsion of torsioned rat testis attenuates ischemia reperfusion injury
    (W B Saunders Co-Elsevier Inc, 2008) Akcora, Bulent; Altug, Muhammed E.; Balci, Ali; Hakverdi, Sibel; Yonden, Zafer; Akbas, Ali; Ozturk, Atakan
    Aim: This study was designed to investigate effect of gradual detorsion on testicular ischemia reperfusion injury. Materials and Methods: A total of 21 male rats were divided into 3 groups, each containing 7 rats. Torsion was created by rotating the left testis 720 degrees in a clockwise direction. Group I underwent sham operation. Group 2 (sudden detorsion) served as a torsion/detorsion group, receiving 2 hours torsion and 2 hours detorsion. In group 3, 360 degrees detorsion was done for 20 minutes after 720 degrees torsion for 2 hours. Then, testis was done full detorsion for 100 minutes. At the end of the experiments (fourth hour), left orchiectomy was performed to measure the tissue levels of malondialdehyde (MDA), superoxide dismutase, and glutathione peroxidase and to perform histologic examination in testes. Results: The MDA levels of testis tissues were significantly increased in the sudden detorsion group as compared with the sham group. We found decrease of the MIDA level in gradual detorsion group, but it was not a statistically significant amount. Significant decrease was found in the superoxide dismutase and glutathione peroxidase activities in the sudden detorsion group as compared with the sham and gradual detorsion groups. Histologic examinations were in accordance with the testicular tissue MDA levels. Conclusion: In the light of our biochemical and histopathologic findings, we can say that gradual detorsion has a trend to decrease the degree of testicular reperfusion injury in the rat torsion/detorsion model. (C) 2008 Elsevier Inc. All rights reserved.