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Öğe Association of left ventricular diastolic function abnormalities with aortic elastic properties in asymptomatic patients with type 2 diabetes mellitus. A tissue doppler echocardiographic study(Wiley, 2008) Seyfeli, E.; Duru, M.; Saglam, H.; Akgul, F.; Kuvandik, G.; Kaya, H.; Yalcin, F.Background: The aim of this study was to investigate the association between the aortic elastic properties and the left ventricular diastolic function measured by tissue Doppler echocardiography (TDE) in asymptomatic type 2 diabetes mellitus. Methods: Fifty-seven asymptomatic patients with type 2 diabetes (33 women, mean age: 49 +/- 6 years) and 25 healthy control subjects (19 women, mean age: 46 +/- 7 years) were included in the present study. Diastolic filling indices were measured by conventional (CE) and tissue Doppler echocardiography. The aortic elastic properties [Aortic stiffness index (ASI), aortic distensibility and strain] were measured as previous definition. Results: Compared with control subjects, the ratio of LV diastolic abnormalities measured by CE and TDE were found higher in patients with type 2 diabetes (36% and 73.6%, p = 0.001, respectively, and 52% and 89.4%, p < 0.001, for septal annulus; 48% and 89.4%, p < 0.001 for septal basal respectively). The ASI was significantly higher (p < 0.001), aortic distensibility and aortic strain were also significantly lower in patients with type 2 diabetes than control subjects (p < 0.001 and p < 0.001 respectively). In the regression analysis, Ao distensibility was correlated to age (beta = -0.299, p = 0.004), septal basal Em/Am ratio (beta =0.543, p < 0.001) and HDL-cholesterol (beta = 0.192, p = 0.039). ASI was also correlated only to age (beta = 0.255, p = 0.044), the presence of diabetes mellitus (beta = 0.304, p = 0.009), mitral A wave (beta = 0.322, p = 0.013) and mitral annulus Em wave (beta = -0.505, p < 0.001). Conclusion: The aortic elastic function is impaired in asymptomatic patients with type 2 diabetes. Increased ASI and decreased Ao distensibility are closely associated with diastolic filling indices measured by CE and TDE.Öğe Can neurological soft signs be used to identify patients at risk of stroke in sickle cell disease?(Blackwell Publishing, 2006) Melek, I.; Duman, T.; Akgul, F.; Yalcin, F.[Abstract Not Available]Öğe DECREASED HEART RATE VARIABILITY IN SICKLE CELL ANEMIA AS EFFECT OF PULMONARY ARTERIAL HYPERTENSION(Russian Heart Failure Soc, 2019) Akgul, F.; Batyraliev, T. A.; Fettser, D., V; Seyfeli, E.; Arystan, A. G.; Seydaliyeva, T.; Gali, E.Decreased heart rate variability (HRV) is associated with increased mortality risk in various diseases. The objective of this investigation: to study HRV in patients with sickle cell anemia (SCA) and to assess the effect of pulmonary arterial hypertension (PAH) on HRV in these patients. Materials and methods. HRV registration and Doppler echocardiographic assessment of systolic pulmonary arterial pressure (PAP) was carried out in 61 stable patients with SCA and 24 healthy subjects. Results. Low frequency power (LFP) and high frequency power (HFP) were decreased in SCA patients compared to healthy subjects. Among SCA patients, PAH patients had lower LFP and HFP than patients without PAH. In SCA patients, systolic PAP showed significant negative correlation with LFP and HFP. Conclusion. HRV is significantly decreased in SCA patients, especially in those with PAH. HRV may be particularly useful in early detection of PAH patients who may have worse prognosis and higher mortality risk.Öğe Doppler tissue imaging of the left and right ventricular function in multiple sclerosis(Blackwell Publishing, 2006) Melek, I.; Duman, T.; Akgul, F.; Seyfeli, E.; Yalcin, F.[Abstract Not Available]Öğe Myocardial perfusion is preserved in patients with psoriasis without clinically evident cardiovascular disease(Wiley, 2009) Yalcin, H.; Balci, D. D.; Ucar, E.; Ozcelik, N.; Tasci, C.; Seyfeli, E.; Akgul, F.Psoriasis is associated with a premature atherosclerosis due to the chronic inflammatory process. To evaluate the effect of disease process on myocardial perfusion, we planned to perform 99mTc-MIBI myocardial perfusion single photon emission computed tomography (SPECT) in patients with psoriasis. The study group consisted of 28 psoriasis patients (17 men, 11 women), aged 18-76 years, and mean age 41.2 +/- 14.1 years. The patients were selected among those who were older than 18 years and longer than 10 years of disease duration with more than two times of systemic treatment. All patients underwent 99mTc-MIBI myocardial perfusion SPECT with the same day protocol. We detected various risk factors including smoking habits in 7, family history of cardiovascular disease in 4, hypertension in 1, hyperlipidemia in 9 patients. We completed myocardial perfusion SPECT for each patient and found normal perfusion pattern in SPECT images. We detected that myocardial perfusion is preserved in the patients with psoriasis. The majority of acute heart attacks are caused by noncritical coronary stenosis and this may be an explanation for increased cardiovascular risk in these patients despite normal coronary perfusion.Öğe REGIONAL LEFT VENTRICULAR PERFORMANCE IN HYPERTENSIVE PATIENTS WITH/WITHOUT LEFT VENTRICULAR HYPERTROPHY (LVH)(Lippincott Williams & Wilkins, 2009) Yalcin, F.; Topaloglu, C.; Seyfeli, E.; Akgul, F.[Abstract Not Available]
