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Öğe CASES OF INCIDENTAL PAPILLARY CARCINOMA IN THYROIDECTOMY MATERIALS IN THE ELDERLY(Carbone Editore, 2014) Yanik, Serdar; Karaca, Turgut; Akkoca, Ayse Neslin; Ozdemir, Zeynep Tugba; Kaynar, Aysegul; Cincin, Tarik Gandi; Yanik, Semra VatanObjective: Papillary microcarcinomas constitute more than half of thyroid cancers and incidentally detected between 2.7% and 36% ratios in all age groups in autopsy studies. Our aim in this study was to evaluate the incidental papillary thyroid carcinoma in surgical materials sent to the pathology department of 60 years and older patients. Materials and methods: In this study, 307 thyroid surgery materials were screened from the archive of the Department of Pathology in Iskenderun State Hospital between January 2012 and November 2013. 27 thyroid specimens of patients over 60 years and older with definite diagnosis were evaluated. Results: Between the ages of 60 to 84 the mean age of the patients was 65.70 +/- 5.60. 19 (70.37%) of the patients were females, 8 (29.63%) of the patients were males. Histopathological examination of the subjects revealed nodular goiter in 16 (59.26%) cases, lymphocytic thyroiditis in 3 (11.11%) cases, granulomatous thyroiditis in one (3.70%) case, thyroid tumors in 6 (22.22%) cases. In this age group no benign tumors ( adenomas ) have been detected and all of the six tumors (22.22%) were malignant. Type of cancer were detected as oncocytic carcinoma in one(3.70%) case and papillary carcinoma in 5 (19.52%) cases. Conclusion: In our study we detected that 22.22 % of thyroid pathologies of over 60 years old patients were malignant . In this study, although the number of cases is small, we reached a remarkable conclusion in terms of the frequency of malignant thyroid pathologies in the elderly. Further prospective studies with a greater number of patients will be beneficial.Öğe Does menopause effect nasal mucociliary clearance time?(Springer, 2015) Ozler, Gul Soylu; Akbay, Ercan; Akkoca, Ayse Neslin; Karapinar, Oya Soylu; Simsek, Gokce OzelThe aim of this study was to investigate the effect of menopause on nasal mucociliary clearance time by comparing the results of premenopausal and postmenopausal women. A total of 60 women met the criteria and were divided into two groups: premenopausal women (n = 30) and postmenopausal women (n = 30). Nasal mucociliary clearance time of these women was measured and compared. Moreover, the correlation between nasal mucociliary clearance time and menopause duration in postmenopausal women was evaluated. Statistical analysis was performed using the SPSS (Statistical Package for the Social Sciences) 13.0 Evaluation for Windows. Normal distribution of continuous variables was tested with Kolmogorov-Smirnov test. Chi square test was used for comparisons between categorical variables. Kruskal-Wallis test and Mann-Whitney U tests were used for continuous variables when comparing the groups. The statistically significant level was accepted as p value < 0.05. The mean nasal mucociliary clearance time in premenopausal and postmenopausal women was 11.43 +/- A 2.81 (7-16) and 16.76 +/- A 2.73 (12-22), respectively. The mean nasal mucociliary clearance time in postmenopausal women was significantly longer than in premenopausal women (p < 0.0001). Also, there was positive correlation between menopause duration and nasal mucociliary clearance time in postmenopausal women (r = 0.833, p < 0.0001). The clinicians must keep in mind that nasal mucociliary clearance time in postmenopausal women is prolonged and must follow up women in postmenopausal period more closely for respiratory tract diseases, sinonasal and middle ear infections.Öğe Increased Density of Demodex folliculorum Mites in Pregnancies with Gestational Diabetes(Karger, 2014) Kurt, Raziye Keskin; Kaya, Ozlem Aycan; Karateke, Atilla; Silfeler, Dilek Benk; Karapinar, Oya Soylu; Akkoca, Ayse Neslin; Hakverdi, Ali UlviObjective: To investigate the presence of Demodex in patients with gestational diabetes and the impact of glucose regulation on Demodex density in gestational diabetes. Subjects and Methods: The study population consisted of 33 patients with gestational diabetes and 30 pregnant women without gestational diabetes (control group). The age, parity, gestational age, and BMI of the study group were recorded and the patients were divided into 2 groups, i. e. those with regulated and unregulated glucose levels, according to their postprandial 1st-and 2nd-hour glucose values. A standardized skin surface biopsy method was used to determine if patients had Demodex folliculorum infestation (> 5 mites/cm 2 of skin). Results: Patients with gestational diabetes had a statistically significantly higher Demodex density compared to the control group (24.2 vs. 3.3%; p < 0.001). Furthermore, a significantly higher proportion of gestational diabetes patients with unregulated glucose levels had a higher Demodex density compared to those in the regulated subgroup (6/19 vs. 2/14; p = 0.001). Conclusion: Our study revealed that the Demodex density was increased in gestational diabetes patients. Further, poor glucose regulation could be the mechanism responsible for the increased Demodex density in gestational diabetes patients with unregulated glucose levels compared to those with regulated glucose levels. (C) 2014 S. Karger AG, BaselÖğe THE PREVALENCE OF URINARY INCONTINENCE, SEXUAL DYSFUNCTION AND QUALITY OF LIFE IN WOMEN OF REPRODUCTIVE AGE ADMITTED TO UROGYNECOLOGY DEPARTMENTS(Carbone Editore, 2014) Akkoca, Ayse Neslin; Kurt, Raziye; Ozdemir, Zeynep Tuba; Yengil, Erhan; Ozer, Cahit; Arica, Secil; Ozler, SerkanAim: Urinary incontinence (Ul) is fairly common among women and reduces common emotional and psychological well-being and also a phenomenon that weakens sexual life. At the same time social activities and relationships; family life, his relationship with his Wife is adversely affected. In this study of prevalence of Ul and the sexual dysfunction(SD) and quality of life. were examined in women of reproductive age who admitted family medicine, obstetrics, urology clinics With various symptoms. (frequent urination; urinary burning; pelvic pain, urinary incontinence, vaginal discharge and similar complaints). Materials and methods: The study included a total of 665 female patients of 15-49 years of age admitted to Family Medicine, Obstetrics and Gynecology, and Urology polyclinics in Mustafa Kemal University Faculty of Medicine, Training and Research Hospital during October 2013-January 2014 with various complaints. General survey form ICIQ-SF (International Consultation on Incontinence Short Form), FSFI (Female Sexual Function Index) form; and EORTC QLQ-C30 (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30) version 3.0 were applied to these patients The general survey form addressed demographic characteristics, risk factor for urinary incontinence, concomitant diseases, anamnesis including medical history and family history. The data obtained in the study were assessed for statistical significance by using Student's (t-test, Mann Whitney U test, Chi,square test and Fisher's Exact Chi-square test. Results: The sociodemographic characteristics of the women were; mean age was 31.85 +/- 9.495 (SD) and mean body mass index (BMI) value was 26.39 +/- 4.03. Obstetric history was as follows; number of normal vaginal births was 317 (47,66%);number of caesarean sections 471 (70.8%); number of deliveries of infant over 4 kg of birth weight 138 (20.8%) and number of multiple gestations resulting in live birth was 60(9%) 235(35 3%) women had previous history of surgery to pelvic floor and 203 (30,5%). of had previous history of abdominal surgery (except cesarean section). Frequency of Ul was 42,7%(284 women) Situation that provokes Ul; mixed type at 95 (143%) women, stress type at 133 (20%) women, urge type at 56 (8.4%) women. The effect on daily life was scored(those who report an effect of 8 on a scale to 10 was 159 (23.9%) of). There was chronic disease at 175(26,4%) of them, disc herniation at 36 (5.4%) of, involuntary defecation at74 (11.1%)of, involuntary flatulence at 191 (28.7%) of, haemorrhoids at 405 (60.9%)of urinary tract infection at 244 (36,7%), vaginitis 1-2 times a year at 352 (52.9%) women. Sexual dysfunction (FSFI according to survey results); 215 (32.3%) Women have-not heard of sexual desire in the past month. Self-confidence about being sexually driven present at only in 222 (33.4%) women. 307 (46.2%) women dont feel wetness during sexual intercourse. 136(20.5%) women say sexual intercourse is not satisfactory. 57.9% of all cases not satisfied with your sexual life. Painful intercourse at 74 (11.1%) women. Conclusion: Urinary incontinence in female population is quite a common health problem. A large majority of women perceive it as a result of aging and female gender and do not seek medical assistance it is important to detect this problem and relevant risk factor among patients who admit to palyclinics. This approach would improve the treatnient of this condition which affects quality of life and sexuality.Öğe RELATIONSHIP BETWEEN DEMODEX FOLLICULORUM AND ALLERGIC RHINITIS IN ADULTS(Carbone Editore, 2014) Yengil, Erhan; Cevik, Cengiz; Kaya, Ozlem Aycan; Taner, Melis; Akkoca, Ayse Neslin; Ozer, CahitBackground and aim: Allergic rhinitis (AR) is a chronic disease, which exhibits rapid increase in recent years and affects approximately 30-40% of the population worldwide. Demodex folliculorum (DF) is an ectoparasite, which is prevalent in human skin. The aim of the present study was to investigate the frequency of DF at eyelashes and cheek in patients with allergic rhinitis and controls. Materials and methods: The study included 63 patients with allergic rhinitis and 65 healthy individuals. For DF evaluations, 4 eyelashes were taken from all individuals. Five samples of standardized skin surface biopsies (SSSB) were taken from each subject from the forehead, cheeks, jaw and nose. Results: For eyelashes, the frequencies of DF were found as 50.8% in AR group, whereas 38.1% in control group. For face, it was found as 38.1% in AR group, whereas 12.3% in control group. The frequencies of DF at face and eyelashes were found to be significantly higher in patients with AR than controls (p=0.001 and p=0.0001, respectively). The DF was detected at eyelashes in 63.9% of the patients with ocular symptoms vs. 33.3% of those without (OR: 3.5 (95% CI: 1.2-10.1); p=0.016), whereas it was detected at face in 52.8% of the patients with ocular symptoms vs. 18.5% of those without (OR: 4.9 (95%CI: 1.5-15.8); p=0.008). Conclusion: The frequencies of DF at eyelashes and face were significantly higher in patients with AR than healthy individuals. The higher frequency of DF in patients with AR suggests that AR facilitate the colonization of this mite.Öğe Smoking Among Medical School Students and Attitudes against Smoking(Duzce Univ, 2014) Yengil, Erhan; Cevik, Cengiz; Demirkiran, Gokhan; Akkoca, Ayse Neslin; Ozler, Gul Soylu; Ozer, CahitObjective: The aim of this study was to observe smoking and nicotine addiction status and of medical school students and to establish relating factors. Methods: A questionnaire was applied to students who were in Mustafa Kemal University Medical School in 2013-2014 semesters about smoking behavior, age of onset, thought of quitting, attitudes against, nicotine addiction, use of alcohol and other drugs. Results: Of the 712 students 54.5% (388) were male, while 45.5% (324) were female and overall smoking rate was 25.6%. The average age of smoking initiation was 17.7 +/- 2.8 years. The overall smoking rates are increasing every year of school. 40.1% (73) of smokers reported the smoke in the hospital, while 33.5% (61) of them smoke only in the separated area. Almost half of the smokers (51.6%, 94) had very low, 19.2% (35) low, 8.8% (16) moderate, 14.3% (26) high, and 6% ( 11) very high level of nicotine dependency. Of the participants 46.3% (330) reported no special anti-tobacco efforts against in the society, whether only 2.4% (17) of them stated regular counseling. Non smokers showed more effort than smokers (p=0.0001). 40.1% of the smokers reported that medical education didn't affect their attitude against smoking, while 19.8% stated that it affected negatively. Conclusion: In conclusion the study found a higher smoking prevalence compared to developed countries Medical school curricula need to be reframed in the context of smoking cessation counseling in order to win the war against tobacco use and addiction.Öğe TNM and Modified Dukes staging along with the demographic characteristics of patients with colorectal carcinoma(E-Century Publishing Corp, 2014) Akkoca, Ayse Neslin; Yanik, Serdar; Ozdemir, Zeynep Tugba; Cihan, Fatma Goksin; Sayar, Suleyman; Cincin, Tarik Gandi; Cam, AkinAim: Colon adenocarcinoma, is the most common cancer in gastrointesinal system (GIS). The whole world is an important cause of morbidity and mortality. TNM and modified Dukes classification which has great importance in the diagnosis and treatment of Colorectal cancer (CRC). TNM and Modified Dukes classification results of histopathological examination and the demographic characteristics of patients and their relation were investigated. Materials and methods: Lower gastrointestinal operation results of 85 patients were examined accepted to clinical Pathology between January 1997-November 2013. Colon cancer had been diagnosed at 85 patients with pathology materials and staging was done according to the TNM and Modified Duke classification. The demographic characteristics of patients, differentiation grade, lymph node involvement, serous involvement were evaluated retrospectively. Results: In this study 37 patients (43.52%) were men and 48 (56.47%) were women. Ages of patients were between 19 and 87 with a mean age of 57.31 +/- 15.31. Lymph node, differentiation, serosa involvement, Modified Dukes and TNM classification was assessed according to sex and age. TNM classification by sex was not statistically significant (p > 0.05). There was no statistically significant relationship between age and differentiation (p = 0.085). Value of differentiation increased towards from 1 to 3 inversely proportional to age. So young patients defined as well-differentiated at the conclusion. Negative relationship was evaluated between age and TNM Class variables. As a result, the relationship between age and TNM was not significant (p > 0.05). However, with increasing age the degree of staging was also found to increase. TNM classification was associated with the differentiation and it was significant (p = 0.043). Conclusion: Colon cancer, when contracted at an early stage, it is suitable for surgery and curative treatment can be done with minimal morbidity and mortality. However, some of the patients have advanced disease at diagnosis and their 5-year survival rate is only 8%. Every year there is prolongation of overall survival of colon cancer. It is so common cancer type so that determination of prognostic factors, disease staging and treatment strategy which affects survival is significant.
