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  • Küçük Resim
    Öğe
    The effects of caffeic acid phenethyl ester (CAPE) treatment on rheumatologic parameters and iron metabolism in diabetic rats
    (Univ Zagreb Vet Faculty, 2015) Aytekin, Ismail; Devrim, Alparslan K.; Ozturk, Aliye S.; Aksit, Hasan; Mamak, Nuri; Hismiogullari, Sahver E.
    Diabetology and rheumatology have much in common, including many biochemical features. Diabetic cases suffer excessively from common musculoskeletal conditions. The present study aimed to explore the association between the caffeic acid phenethyl ester (CAPE) treatment and the standard parameters of diabetic and rheumatologic controls. Serum anti-streptolysin-O (ASO), C-reactive protein (CRP), rheumatoid factor (RF) titers and glucose (GLU), cholesterol (CHOL), triglyceride (TG), high density lipoprotein (HDL), very low density lipoprotein (VLDL), alkaline phosphatase (ALP), gamma-glutamyl transferase (GUT), sodium (Na), potassium (K), chloride (Cl), calcium (Ca), phosphorus (P), uric acid (UA), iron (Fe), iron-binding capacity (IBC), total iron-binding capacity (TIBC) and superoxide dismutase (SOD) levels were measured in 22 female Wistar-Albino rats. The animals were divided into three groups: group 1: non-diabetic rats as control; group 2: streptozotocin (STZ)-induced, untreated diabetic rats; and group 3: STZ-induced, CAPE-treated diabetic rats. Levels of GLU were increased in group 2. ASO values were decreased in group 3. TG and VLDL levels were increased in group 3 compared with the group 1. Higher UA levels were detected in group 3 compared with group 2. The levels of Fe and TIBC were decreased in group 3. The results of the present study indicate the reducing effect of CAPE on the serum levels of diabetic and rheumatologic parameters in diabetic rats.
  • Küçük Resim
    Öğe
    PROTECTIVE EFFECTS OF N-ACETYL CYSTEINE ON OLIGOSACCHARIDE RESIDUES IN THE EXPERIMENTAL LIVER INTOXICATION FORMED BY CARBONTETRACHLORIDE (CCL4) IN RATS
    (Carbone Editore, 2016) Aksit, Dilek; Atici, Yasemin; Aksit, Hasan; Kara, Hatibe; Bildik, Aysegul; Seyrek, Kamil
    Aim: In this study, we aimed to investigate the protective effects of N-acetyl cysteine (NAC) that is known playing an important role in detoxification reactions of biomolecules, on rat liver tissue exposed to carbon tetrachloride (CCl4). Materials and methods: Twenty-eight rats were divided into four groups each containing seven rats: Control groups (Group 1: Olive oil group, Group 2: Olive oil+NAC group) and experimental groups (Group 3: CCl4 group, Group 4: CCl4+NAC group). CCl4 was given in 1 ml/kg doses intraperitoneally (i.p.), NAC was given in 50 mg/kg doses. Oligosaccharide units were detected histochemically using biotin labeled lectins. Results: Histochemically, NAC showed no remarkable effect on the staining intensity of biotin labeled lectins. Liver enzyme activities and plasma protein levels were measured using commercial available kits. Compared to the control group in CCl4 given rats AST, GGT and ALP activities increased significantly (P<0.001), while NAC administration alleviated the toxic effects of CCl4. CCl4 decreased serum albumin concentration significantly (P<0.05), however NAC annihilated negative effect of CCl4 on albumin concentration. The alterations in total protein levels and ALT activities remained insignificant (P>0.05). Conclusion: Our findings indicate that cells may increase their oligosaccharide units to protect themselves from the toxic effects of CCl4 and NAC may support cells to scavenge free radicals induced by CCl4.
  • [ N/A ]
    Öğe
    Protective effects of N-acetyl cysteine on oligosaccharide residues in the experimental liver intoxication formed by carbontetrachloride (CCL4) in rats
    (A. CARBONE Editore, 2016) Aksit, Dilek; Atici, Yasemin; Aksit, Hasan; Kara, Hatibe; Bildik, Aysegul; Seyrek, Kamil
    Aim: In this study, we aimed to investigate the protective effects of N-acetyl cysteine (NAC) that is known playing an important role in detoxification reactions of biomolecules, on rat liver tissue exposed to carbon tetrachloride (CCl4). Materials and methods: Twenty-eight rats were divided into four groups each containing seven rats: Control groups (Group 1: Olive oil group, Group 2: Olive oil+NAC group) and experimental groups (Group 3: CCl4 group, Group 4: CCl4+NAC group). CCl4 was given in 1 ml/kg doses intraperitoneally (i.p.), NAC was given in 50 mg/kg doses. Oligosaccharide units were detected histochemically using biotin labeled lectins. Results: Histochemically, NAC showed no remarkable effect on the staining intensity of biotin labeled lectins. Liver enzyme activities and plasma protein levels were measured using commercial available kits. Compared to the control group in CCl4 given rats AST, GGT and ALP activities increased significantly (P < 0.001), while NAC administration alleviated the toxic effects of CCl4. CCl4 decreased serum albumin concentration significantly (P < 0.05), however NAC annihilated negative effect of CCl4 on albumin concentration. The alterations in total protein levels and ALT activities remained insignificant (P > 0.05). Conclusion: Our findings indicate that cells may increase their oligosaccharide units to protect themselves from the toxic effects of CCl4 and NAC may support cells to scavenge free radicals induced by CCl4.