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    Comparative evaluation of the effects of florfenicol and tulathromycin on clinical recovery and acute phase proteins in undifferentiated natural bovine respiratory disease
    (Ecole Nationale Veterinaire Toulouse, 2010) Arslan, H. H.; Yavuz, O.; Nisbet, C.; Cenesiz, S.; Aksu, D. S.
    In this study, the effects of florfenicol and tulathromycin on clinical recovery and acute-phase proteins in bovine respiratory diseases (BRD) were evaluated under the field conditions. A total of 30 local race feedlot cattle were used in the study. Twenty naturally infected beef and 10 healthy beef were used for the experimental and control groups, respectively. Sick animals were randomly divided into two groups of 10 and subcutaneously 40 mg per kg florfenicol was administrated in group I and 2.5 mg per kg tulathromycin was administrated in group II as single dose. The animals were clinically examined before (0 h) and 9 days after the treatment. Also, blood samples were taken and serum haptoglobin and serum amyloid A concentrations were measured before and 9 days after the treatment. It was concluded that although the clinical findings and recovery were not always correlated with serum acute phase proteins levels, florfenicol and tulathromycin can be effective for BRD therapy under field conditions.
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    Effects of Sildenafil Citrate on the Hematological Parameters in the Early Phase of Wound Healing in Diabetic Rats
    (Academic Journals Inc, 2011) Tas, A.; Karasu, A.; Comba, B.; Aksu, D. S.; Duz, E.; Tanritanir, P.
    In this study Investigation of effects of sildenafil citrate on some of the hematological parameters in the early phase of wound healing in diabetic rats was aimed in this study. Total 30 rats were used in the study. Rats were divided into three groups equal in number (control-non diabetic, diabetic and diabetic+Sc). While no treatment was given to the control-non diabetic and diabetic groups, sildenafil citrate was given to the diabetic+Sc group intraperitoneally with a dosage of 0.7 mg/kg/day dosage for 3 days after creating wounds: under ketamine anesthesia, a circular, full thickness, standard wound was created on the back of each rat by using a 0.8 cm sterile punch. Cardiac blood was drawn in tubes containing EDTA from each group before the creation of wounds and on days 1, 2 and 3 following the creation of wounds. Differential leukocyte counts were determined in blood samples containing anticoagulant. For this purpose, blood smears were prepared from blood samples and stained with Giemsa method. It was found that, while neutrophil counts increased in all the groups during the wound-healing periods with the increasing number of days, lymphocyte counts reduced and in control and Sc+diabetic groups, monocyte counts increased. As a result, it was concluded that Sc plays an important role in eliminating the pressure on the cellular activities in the early period of wound healing and continuance of the inflammatory process and wound healing within normal limits and also that this could be demonstrated with hematological analyses.