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    Intralesional Vitamin D Injection May Be an Effective Treatment Option for Warts
    (Sage Publications Inc, 2016) Aktas, Habibullah; Ergin, Can; Demir, Betul; Ekiz, Ozlem
    Background: Plantar warts are typically resistant to treatment. In recent years, treatments have included administration of intralesional tuberculin; measles, mumps, rubella vaccine; and Candida albicans antigen immunotherapy. To the best of our knowledge, there are no reports of intralesional vitamin D administration for the treatment of warts. Aim: To evaluate the efficacy and safety of intralesional vitamin D treatment for plantar warts. Methods: Twenty patients with single or multiple plantar warts were included in this study. Vitamin D-3 (0.2 mL, 7.5 mg/mL) was injected into the base of the warts after prilocaine (0.1 mL, 20 mg/mL) injection. A maximum of 5 warts were treated in 1 session, with at maximum 2 injections performed at 4-week intervals. Results: In total, 16 of 20 patients (80%) showed complete resolution of warts, and 1 patient showed partial resolution. Three patients failed to show any response. No recurrence or serious adverse effects were observed. Conclusion: Intralesional vitamin D-3 may be an effective treatment option for warts.
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    The role of serum vitamin D levels in vitiligo
    (Termedia Publishing House Ltd, 2016) Karagun, Ebru; Ergin, Can; Baysak, Sevim; Erden, Gonul; Aktas, Habibullah; Ekiz, Ozlem
    Introduction: Vitiligo is a common acquired pigmentary skin disorder. Vitamin D is responsible for skin pigmentation, increases tyrosinase activity and melanogenesis, and exhibits immunoregulatory functions. Low levels of vitamin D are associated with many autoimmune diseases, including systemic lupus, diabetes mellitus, rheumatoid arthritis, multiple sclerosis and alopecia areata. Few reports have evaluated serum vitamin D levels in vitiligo patients, and their results are conflicting. Aim: To evaluate serum vitamin D levels of vitiligo patients and compare the results with controls. Material and methods: In total, 50 vitiligo patients and 47 controls were enrolled in the study. Vitamin D levels were measured from blood samples. Group comparisons were performed using appropriate statistical methods. Results: The patients had lower serum vitamin D levels than the controls, but this difference was not significant (p = 0.570). Conclusions: It remains unknown whether vitamin D deficiency causes vitiligo. Larger controlled studies are required to prove whether low circulating vitamin D is a causative factor in vitiligo.